The recent unprecedented progress in ageing research and drug discovery brings together
fundamental research and clinical applications to advance the goal of promoting healthy …

Reactivation of retroelements in the human genome has been linked to aging. However,
whether the epigenetic state of specific retroelements can predict chronological age remains …

Background Geroscience focuses on interventions to mitigate molecular changes
associated with aging. Lifestyle modifications, medications, and social factors influence the …

Genome-wide association studies (GWAS) with proteomics are essential tools for drug
discovery. To date, most studies have used affinity proteomics platforms, which have limited …

Individuals, organs, tissues, and cells age in diverse ways throughout the lifespan.
Epigenetic clocks attempt to quantify differential aging between individuals, but they typically …

Age-related alterations in immune function are believed to increase risk for a host of age-
related diseases leading to premature death and disability. Programming of the immune …

Extract Lung function and development are critical to long-term respiratory health [1, 2].
Identifying modifiable factors, particularly within the early life period, that can be targeted to …

Many lifestyle-related diseases such as cancer, dementia, myocardial infarction, and stroke
are known to be caused by aging, and the WHO's ICD-11 (International Classification of …

Background 1 H-NMR metabolomics and DNA methylation in blood are widely known
biomarkers predicting age-related physiological decline and mortality yet exert mutually …

Importance: Schizophrenia is associated with increased age-related morbidity, mortality, and
frailty, which are not entirely explained by behavioral factors. Prior studies using epigenetic …