Alpha‐amylase as molecular target for treatment of diabetes mellitus: A comprehensive review

N Kaur, V Kumar, SK Nayak, P Wadhwa… - Chemical biology & …, 2021 - Wiley Online Library
The alpha (α)‐amylase is a calcium metalloenzyme that aids digestion by breaking down
polysaccharide molecules into smaller ones such as glucose and maltose. In addition, the …

Flavonoids as potential agents in the management of type 2 diabetes through the modulation of α-amylase and α-glucosidase activity: a review

C Proença, D Ribeiro, M Freitas… - Critical Reviews in Food …, 2022 - Taylor & Francis
Abstract Type 2 diabetes (T2D) is one of the most prevalent metabolic diseases worldwide
and is characterized by increased postprandial hyperglycemia (PPHG). α-Amylase and α …

Phytochemistry and pharmacology of natural prenylated flavonoids

HW Lv, QL Wang, M Luo, MD Zhu, HM Liang… - Archives of Pharmacal …, 2023 - Springer
Prenylated flavonoids are a special kind of flavonoid derivative possessing one or more
prenyl groups in the parent nucleus of the flavonoid. The presence of the prenyl side chain …

The inhibitory effects of flavonoids on α-amylase and α-glucosidase

J Zhu, C Chen, B Zhang, Q Huang - Critical Reviews in Food …, 2020 - Taylor & Francis
The objective of this review is to summarize knowledge on the inhibitory effects (IEs) of
flavonoids on α-amylase (αA) and α-glucosidase (αG) relevant to the search of substitutes of …

Inhibition of α-glucosidase and α-amylase by flavonoid glycosides from Lu'an GuaPian tea: molecular docking and interaction mechanism

F Hua, P Zhou, HY Wu, GX Chu, ZW Xie, GH Bao - Food & function, 2018 - pubs.rsc.org
Green tea may favorably modulate blood glucose homeostasis, and regular consumption of
green tea can prevent the development of type 2 diabetes mellitus. In this study, α …

Coumarins as versatile therapeutic phytomolecules: A systematic review

MK Hussain, S Khatoon, MF Khan, MS Akhtar… - Phytomedicine, 2024 - Elsevier
Background Coumarins, abundantly distributed in a plethora of biologically active
compounds, serve as a fundamental motif in numerous natural products, drugs, and …

Pharmacology and phytochemistry of Ecuadorian medicinal plants: An update and perspectives

C Armijos, J Ramírez, M Salinas, G Vidari, AI Suárez - Pharmaceuticals, 2021 - mdpi.com
The use of plants as therapeutic agents is part of the traditional medicine that is practiced by
many indigenous communities in Ecuador. The aim of this study was to update a review …

Recent advances of α-glucosidase inhibitors: A comprehensive review

N Agrawal, M Sharma, S Singh… - Current topics in …, 2022 - ingentaconnect.com
Background: Diabetes mellitus (DM) is a critical health issue prevailing in nearly half a
billion people worldwide. It is one of the most threatening metabolic diseases. Type 2 DM is …

In vitro and in silico perspectives on biological and phytochemical profile of three halophyte species—A source of innovative phytopharmaceuticals from nature

G Zengin, Z Aumeeruddy-Elalfi, A Mollica, MA Yilmaz… - Phytomedicine, 2018 - Elsevier
Background Halophytes are considered as valuable sources of traditional drugs in different
countries. Purpose The present study aimed to evaluate biological and chemical fingerprints …

A review on bioactive iridoids in edible fruits–from garden to food and pharmaceutical products

D Przybylska, AZ Kucharska… - Food Reviews …, 2023 - Taylor & Francis
Iridoids are natural monoterpenoids, widely distributed in ornamental plants, herbs, and
medicinal plants, but particularly in the green parts of plants. Their significance arises from …