It is well known that cardiovascular disease manifests differently in women and men. The
underlying causes of these differences during the aging lifespan are less well understood …

Nearly all cardiovascular diseases show sexual dimorphisms in prevalence, presentation,
and outcomes. Until recently, most clinical trials were carried out in males, and many animal …

Fibrosis, which is characterized by excessive extracellular matrix (ECM) deposition, is a
wound-healing response to organ injury and may promote cancer and failure in various …

Aging promotes chronic inflammation, which contributes to fibrosis and decreases organ
function. Fibrosis, the excessive synthesis and deposition of extracellular matrix …

For years, females were thought of as smaller men with complex hormonal cycles; as a
result, females have been largely excluded from preclinical and clinical research. However …

Objective The aims of our study were to investigate the sex differences in late gadolinium
enhancement (LGE) using cardiovascular magnetic resonance (CMR) in a single-centre …

Aging promotes structural and functional remodeling of the heart, even in the absence of
external factors. There is growing clinical and experimental evidence supporting the …

The cardiac fibroblast interacts with an extracellular matrix (ECM), enabling myofibroblast
maturation via a process called mechanosensing. Although in the aging male heart, ECM is …

Introduction: Fibroblasts are mesenchymal cells that predominantly produce and maintain
the extracellular matrix (ECM) and are critical mediators of injury response. In the heart …

Background Age and sex are prominent risk factors for heart failure and determinants of
structural and functional changes of the heart. Cardiac fibroblasts (cFB) are beyond their …