Clinical course and management of COVID-19 in the era of widespread population immunity

EA Meyerowitz, J Scott, A Richterman, V Male… - Nature Reviews …, 2024 - nature.com
The clinical implications of COVID-19 have changed since SARS-CoV-2 first emerged in
humans. The current high levels of population immunity, due to prior infection and/or …

Persistent SARS-CoV-2 infection: significance and implications

HM Machkovech, AM Hahn, JG Wang… - The Lancet Infectious …, 2024 - thelancet.com
SARS-CoV-2 causes persistent infections in a subset of individuals, which is a major clinical
and public health problem that should be prioritised for further investigation for several …

Triple combination therapy with 2 antivirals and monoclonal antibodies for persistent or relapsed severe acute respiratory syndrome coronavirus 2 infection in …

M Mikulska, C Sepulcri, C Dentone… - Clinical Infectious …, 2023 - academic.oup.com
Background Severely immunocompromised patients are at risk for prolonged or relapsed
Coronavirus Disease 2019 (COVID-19), leading to increased morbidity and mortality. We …

[HTML][HTML] Combination regimen of nirmatrelvir/ritonavir and molnupiravir for the treatment of persistent SARS-CoV-2 infection: A case report and a scoping review of the …

D Marangoni, RM Antonello, M Coppi… - International Journal of …, 2023 - Elsevier
Immunocompromised patients still experience unpredictable courses of COVID-19, despite
that effective vaccines and drugs against SARS-CoV-2 are now available. Antiviral …

Successful combination treatment for persistent severe acute respiratory syndrome coronavirus 2 infection

O Blennow, J Vesterbacka, T Tovatt… - Clinical Infectious …, 2023 - academic.oup.com
Another recent publication reported success with a combination of monoclonal antibodies, 7
days of remdesivir, and 5 days of nirmatrelvir/ritonavir [2]. Influenced by the report from …

Synergistic Activity of Remdesivir–Nirmatrelvir Combination on a SARS-CoV-2 In Vitro Model and a Case Report

A Gidari, S Sabbatini, E Schiaroli, S Bastianelli… - Viruses, 2023 - mdpi.com
Background: This study aims to investigate the activity of the remdesivir–nirmatrelvir
combination against Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and …

[HTML][HTML] SARS-CoV-2 shedding and evolution in immunocompromised hosts during the Omicron period: a multicenter prospective analysis

Z Raglow, D Surie, JD Chappell, Y Zhu, ET Martin… - medRxiv, 2023 - ncbi.nlm.nih.gov
Background: Prolonged SARS-CoV-2 infections in immunocompromised hosts may predict
or source the emergence of highly mutated variants. The types of immunosuppression …

COVID‐19 after hematopoietic cell transplantation and chimeric antigen receptor (CAR)‐T‐cell therapy

E Kampouri, JA Hill, V Dioverti - Transplant Infectious Disease, 2023 - Wiley Online Library
More than 3 years have passed since Coronavirus disease 2019 (COVID‐19) was declared
a global pandemic, yet COVID‐19 still severely impacts immunocompromised individuals …

Optimizing COVID-19 treatment in immunocompromised patients: early combination therapy with remdesivir, nirmatrelvir/ritonavir and sotrovimab

I Gentile, M Foggia, M Silvitelli, A Sardanelli… - Virology Journal, 2023 - Springer
Background Morbidity and mortality are higher in immunocompromised patients affected by
COVID-19 than in the general population. Some authors have successfully used antiviral …

Successful treatment of prolonged severe acute respiratory syndrome coronavirus 2 infection in patients with immunodeficiency with extended nirmatrelvir/ritonavir …

M Breeden, SL Aitken, JH Baang… - Open Forum …, 2023 - academic.oup.com
Immunocompromised patients with B-cell deficiencies are at risk for prolonged symptomatic
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We describe 4 …