Quantitative structure-activity relationship (QSAR) and quantitative structure-property
relationship (QSPR) models have been extensively used for predicting compounds of …

Three advanced models of pharmacokinetics are described. In the first class are
physiologically based pharmacokinetic models based on in vitro data on transport and …

Classification and regression trees (CART) were evaluated for their potential use in a
quantitative structure-activity relationship (QSAR) context. Models were build using the …

Background Since pregnant women are considerably underrepresented in clinical trials,
information on optimal dosing in pregnancy is widely lacking. Physiologically based …

The volume of distribution (VD) in humans of 179 known drug molecules (acids, bases, and
neutrals) has been modeled using two biomimetic-binding measurements. The phospholipid …

Quantitative structure–pharmacokinetic relationships (QSPkR) have increasingly been used
for the prediction of the pharmacokinetic properties of drug leads. Several QSPkR models …

The paper reports a new mathematical model for understanding the mechanism delivery
from drug release systems. To do this, two drug release systems based on chitosan and …

Pharmacokinetics (PK) has been traditionally dealt with under the homogeneity assumption.
However, biological systems are nowadays comprehensively understood as being …

A suite of four drug deliverance formulations grounded on 5-fluorouracil enclosed in a
chitosan-founded intercellular substance was produced by 3, 7-dimethyl-2, 6-octadienal with …

Purpose. The early prediction of pharmacokinetic behavior is of paramount importance for
saving time and resources and for increasing the success of new drug candidates. The …