[HTML][HTML] Mitochondrial complex I ROS production and redox signaling in hypoxia

CN Okoye, SA Koren, AP Wojtovich - Redox biology, 2023 - Elsevier
Mitochondria are a main source of cellular energy. Oxidative phosphorylation (OXPHOS) is
the major process of aerobic respiration. Enzyme complexes of the electron transport chain …

Dissecting the genetic landscape of GPCR signaling through phenotypic profiling in C. elegans

L Pu, J Wang, Q Lu, L Nilsson, A Philbrook… - Nature …, 2023 - nature.com
G protein-coupled receptors (GPCRs) mediate responses to various extracellular and
intracellular cues. However, the large number of GPCR genes and their substantial …

Redox dysregulation in the tumor microenvironment contributes to cancer metastasis

W Liu, B Wang, M Zhou, D Liu, F Chen… - Antioxidants & Redox …, 2023 - liebertpub.com
Significance: Redox dysregulation under pathological conditions results in excessive
reactive oxygen species (ROS) accumulation, leading to oxidative stress and cellular …

GUCY2C signaling limits dopaminergic neuron vulnerability to toxic insults

L Cheslow, M Byrne, JS Kopenhaver, L Iacovitti… - npj Parkinson's …, 2024 - nature.com
Mitochondrial dysfunction and reactive oxygen species (ROS) accumulation within the
substantia nigra pars compacta (SNpc) are central drivers of dopaminergic (DA) neuron …

[HTML][HTML] Reactive oxygen species drive foraging decisions in Caenorhabditis elegans

AP Bischer, TM Baran, AP Wojtovich - Redox Biology, 2023 - Elsevier
Environmental surveillance-mediated behavior integrates multiple cues through complex
signaling mechanisms. In Caenorhabditis elegans, neurons coordinate perception and …

[HTML][HTML] Stress tolerance in entomopathogenic nematodes: Engineering superior nematodes for precision agriculture

D Maushe, V Ogi, K Divakaran, AMV Mogena… - Journal of invertebrate …, 2023 - Elsevier
Entomopathogenic nematodes (EPNs) are soil-dwelling parasitic roundworms commonly
used as biocontrol agents of insect pests in agriculture. EPN dauer juveniles locate and …

[HTML][HTML] Hypoxia induces food leaving in C. elegans

L Pu, L Zhao, Q Lu, C Chen - Micropublication Biology, 2023 - ncbi.nlm.nih.gov
Hypoxia alters eating behavior in different animals. In C. elegans, hypoxia induces a strong
food leaving response. We found that this behavior was independent of the known O 2 …

Acute avoidance of hydrogen sulfide is modulated by external and internal states in C. elegans

L Pu, L Zhao, J Wang, J Henriksson, P Laurent, C Chen - bioRxiv, 2023 - biorxiv.org
Hydrogen sulfide (H2S) can act as an energy source, a poison and a gasotransmitter in
organisms. We used the robust locomotory responses to H2S in Caenorhabditis elegans to …

Polyethylene glycol as an improved barrier to prevent fleeing in C. elegans

S Beydoun, A Sridhar, M Bhandari… - Micropublication …, 2024 - pmc.ncbi.nlm.nih.gov
Caenorhabditis elegans studies can be constrained by worms escaping standard solid
nematode growth medium (NGM) plates. When worms are in search of food or are avoiding …

A molecular exploration of sensory responses in c. elegans

L Pu - 2023 - diva-portal.org
Sensation provides a pivotal ability, allowing animals to survive in complex environments.
The cues sensed by animals are represented by external stimuli and internal signals …