In 1972, Brazeau et al. isolated somatostatin (somatotropin release-inhibiting factor, SRIF), a
cyclic polypeptide with two biologically active isoforms (SRIF-14 and SRIF-28). This event …

This review summarizes the latest advances that have been made to elucidate the
somatostatinergic system in respect to somatostatin receptor evolution, the development of …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

During neural induction, the 'organizer'of the vertebrate embryo instructs neighbouring
ectodermal cells to become nervous system rather than epidermis. This process is generally …

The volume of extracellular fluid (ECF) is maintained within narrow limits in normal human
subjects, despite day-to-day variations in dietary intake of salt and water over a wide range …

Neuromedin U (NMU) is a neuropeptide with potent activity on smooth muscle which was
isolated first from porcine spinal cord and later from other species,,,,,,,. It is widely distributed …

The superfamily of seven-transmembrane-domain G-protein-coupled receptors (GPCRs) is
the largest and most diverse group of transmembrane proteins involved in signal …

The two mammalian neuropeptides NPFF and NPAF have been shown to have important
roles in nociception, anxiety, learning and memory, and cardiovascular reflex. Two receptors …

We have determined the distribution of receptors for human urotensin‐II (U‐II) in human and
rat CNS and peripheral tissues. In rat,[125I]‐U‐II binding density was highest in the …

We report the identification, cloning and tissue distributions of ten novel human genes
encoding G protein-coupled receptors (GPCRs) GPR78, GPR80, GPR81, GPR82, GPR93 …