In trypanosomes, RNA polymerase II transcription is polycistronic and individual mRNAs are
excised by trans-splicing and polyadenylation. The lack of individual gene transcription …

eIF4E, the mRNA cap-binding protein, is well known as a general initiation factor allowing
for mRNA-ribosome interaction and cap-dependent translation in eukaryotic cells. In this …

Most transcription in Trypanosoma brucei is constitutive and polycistronic. Consequently, the
parasite relies on post-transcriptional mechanisms, especially affecting translation initiation …

Trypanosoma brucei live in mammals as bloodstream forms and in the Tsetse midgut as
procyclic forms. Differentiation from one form to the other proceeds via a growth-arrested …

During their life cycle, Leishmania parasites display a fine-tuned regulation of the mRNA
translation through the differential expression of isoforms of eukaryotic translation initiation …

Human African trypanosomiasis is a neglected parasitic disease for which the current
treatment options are quite limited. Trypanosomes are not able to synthesize purines de …

Recognition of the mRNA 5′ end is a critical step needed for translation initiation. This step
is performed by the cap binding protein eIF4E, which joins the larger eIF4G subunit to form …

Association of the initiation factor eIF4E with the mRNA cap structure is a key step for
translation. Trypanosomatids present six eIF4E homologues, showing a low conservation …

Leishmania parasites cycle between sand fly vectors and mammalian hosts, transforming
from extracellular promastigotes that reside in the vectors' alimentary canal to obligatory …

Translation of most cellular mRNAs in eukaryotes proceeds through a cap-dependent
pathway, whereby the cap-binding complex, eIF4F, anchors the pre-initiation complex at the …