Theoretical perspectives on biological machines

ML Mugnai, C Hyeon, M Hinczewski… - Reviews of Modern Physics, 2020 - APS
Many biological functions are executed by molecular machines, which like man-made
motors are powered by chemical energy, released by adenosine triphosphate hydrolysis …

Gene regulation and cellular metabolism: an essential partnership

RW Carthew - Trends in Genetics, 2021 - cell.com
It is recognized that cell metabolism is tightly connected to other cellular processes such as
regulation of gene expression. Metabolic pathways not only provide the precursor molecules …

Physical bioenergetics: Energy fluxes, budgets, and constraints in cells

X Yang, M Heinemann, J Howard… - Proceedings of the …, 2021 - National Acad Sciences
Cells are the basic units of all living matter which harness the flow of energy to drive the
processes of life. While the biochemical networks involved in energy transduction are well …

Enhancer architecture and chromatin accessibility constrain phenotypic space during Drosophila development

R Galupa, G Alvarez-Canales, NO Borst, T Fuqua… - Developmental Cell, 2023 - cell.com
Developmental enhancers bind transcription factors and dictate patterns of gene expression
during development. Their molecular evolution can underlie phenotypical evolution, but the …

[HTML][HTML] The Drosophila model to interrogate triacylglycerol biology

C Heier, S Klishch, O Stilbytska, U Semaniuk… - … et Biophysica Acta (BBA …, 2021 - Elsevier
The deposition of storage fat in the form of triacylglycerol (TAG) is an evolutionarily
conserved strategy to cope with fluctuations in energy availability and metabolic stress …

[HTML][HTML] Developmental energetics: Energy expenditure, budgets and metabolism during animal embryogenesis

S Ghosh, A Koerte, G Serafini, V Yadav… - Seminars in cell & …, 2023 - Elsevier
Developing embryos are metabolically active, open systems that constantly exchange matter
and energy with their environment. They function out of thermodynamic equilibrium and …

Entropy production in exactly solvable systems

L Cocconi, R Garcia-Millan, Z Zhen, B Buturca… - Entropy, 2020 - mdpi.com
The rate of entropy production by a stochastic process quantifies how far it is from
thermodynamic equilibrium. Equivalently, entropy production captures the degree to which …

The janus-faced role of lipid droplets in aging: insights from the cellular perspective

N Bresgen, M Kovacs, A Lahnsteiner, TK Felder… - Biomolecules, 2023 - mdpi.com
It is widely accepted that nine hallmarks—including mitochondrial dysfunction, epigenetic
alterations, and loss of proteostasis—exist that describe the cellular aging process. Adding …

[HTML][HTML] Comparative Transcriptome Analysis of Henosepilachna vigintioctomaculata Reveals Critical Pathways during Development

YX Zhang, YK Wu, HH Liu, WZ Li, L Jin… - International Journal of …, 2024 - mdpi.com
Henosepilachna vigintioctomaculata is distributed in several Asian countries. The larvae
and adults often cause substantial economic losses to Solanaceae crops such as potato …

Drosophila embryos allocate lipid droplets to specific lineages to ensure punctual development and redox homeostasis

MD Kilwein, TK Dao, MA Welte - PLoS Genetics, 2023 - journals.plos.org
Lipid droplets (LDs) are ubiquitous organelles that facilitate neutral lipid storage in cells,
including energy-dense triglycerides. They are found in all investigated metazoan embryos …