DEAD-box RNA helicases are important regulators of RNA metabolism and have been
implicated in the development of cancer. Interestingly, these helicases constitute a major …

The accumulation of protein aggregates is the hallmark of many neurodegenerative
diseases. The dysregulation of protein homeostasis (or proteostasis) caused by acute …

DEAD-box (DDX) 5 and DDX17, which belong to the DEAD-box RNA helicase family, are
nuclear and cytoplasmic shuttle proteins. These proteins are expressed in most tissues and …

With the development and wide usage of CRISPR technology, the presence of R-loop
structures, which consist of an RNA: DNA hybrid and a displaced single strand (ss) DNA …

Amyotrophic lateral sclerosis (ALS) is a rare, devastating disease, causing movement
impairment, respiratory failure and ultimate death. A plethora of genetic, cellular and …

Aging of human skin is a complex process leading to a decline in homeostasis and
regenerative potential of this tissue. Mitochondria are important cell organelles that have a …

Matrin‐3 (MATR3) is an RNA‐binding protein implicated in neurodegenerative and
neurodevelopmental diseases. However, little is known regarding the role of MATR3 in …

Mutations in the Fused in Sarcoma (FUS) gene cause the familial and progressive form of
amyotrophic lateral sclerosis (ALS). FUS is a nuclear RNA-binding protein involved in RNA …

Abstract GGGGCC (G4C2) hexanucleotide repeat expansion (HRE) in the first intron of the
chromosome 9 open reading frame 72 (C9ORF72) gene is the most common genetic cause …

Hyperactive ribosome biogenesis (RiboSis) fuels unrestricted cell proliferation, whereas
genomic hallmarks and therapeutic targets of RiboSis in cancers remain elusive, and …