Population balance modeling is undergoing phenomenal growth in its applications, and this
growth is accompanied by multifarious reviews. This review aims to fortify the model's …

Glial tumors represent the leading etiology of primary brain tumors. Their particularities lie in
(i) their location in a highly functional organ that is difficult to access surgically, including for …

Purpose The standard of care for treating patients with pancreatic adenocarcinomas
includes gemcitabine (2′, 2′-difluorodeoxycytidine). Gemcitabine primarily elicits its …

Combinations of gemcitabine and trabectedin exert modest synergistic cytotoxic effects on
two pancreatic cancer cell lines. Here, systems pharmacodynamic (PD) models that …

AML is a cancer of the blood and bone marrow which results from the combined effects of
genetic mutations, aberrant interactions in the microenvironment and altered networks of …

Acute myeloid leukaemia is characterized by marked inter-and intra-patient heterogeneity,
the identification of which is critical for the design of personalized treatments. Heterogeneity …

A methodology is developed that determines age‐specific transition rates between cell cycle
phases during balanced growth by utilizing age‐structured population balance equations …

Background AML patients with FLT3/ITD mutations have poor response to cytarabine-based
chemotherapy. FLT3 inhibitors (FLT3i) may resensitize cells to cytarabine (CYT). Improving …

Background In vitro generated dose-response curves of human cancer cell lines are widely
used to develop new therapeutics. The curves are summarised by simplified statistics that …

This work studies three differential equation models of the leukemia cell cycle: a population
balance model (PBM) using intracellular protein expression levels as state variables …