Cell cycle-dependent gene transcription is tightly controlled by the retinoblastoma (RB): E2F
and DREAM complexes, which repress all cell cycle genes during quiescence. Cyclin …

Immunotherapy that harnesses the human immune system to fight cancer has received
widespread attention and become a mainstream strategy for cancer treatment. Cancer …

When gastrointestinal stromal tumour (GIST), the most common form of sarcoma, was first
recognized as a distinct pathological entity in the 1990s, patients with advanced-stage …

Cancer cell dormancy is a process whereby cells enter reversible cell cycle arrest, termed
quiescence. Quiescence is essential for cancer cells to acquire additional mutations, to …

The precise timing of cell cycle gene expression is critical for the control of cell proliferation;
de-regulation of this timing promotes the formation of cancer and leads to defects during …

Gastrointestinal stromal tumor (GIST) provides a paradigm to evaluate new molecularly
targeted therapies and to identify structural and functional mechanisms for drug response …

Tumour dormancy and recurrent metastatic cancer remain the greatest clinical challenge for
cancer patients. Dormant tumour cells can evade treatment and detection, while retaining …

DYRK (dual-specificity tyrosine-regulated kinases) are an evolutionary conserved family of
protein kinases with members from yeast to humans. In humans, DYRKs are pleiotropic …

Here, we provide an overview of the importance of cellular fate in cancer as a group of
diseases of abnormal cell growth. Tumor development and progression is a highly dynamic …

Perfectly orchestrated periodic gene expression during cell cycle progression is essential for
maintaining genome integrity and ensuring that cell proliferation can be stopped by …