Human accelerated regions (HARs) are the fastest-evolving sequences in the human
genome. When HARs were discovered in 2006, their function was mysterious due to scant …

With the goal of mapping genomic activity, international projects have recently measured
epigenetic activity in hundreds of cell and tissue types. Chromatin state annotations …

The human genome is marked by several singular and combinatorial histone modifications
that shape the different states of chromatin and its three-dimensional organization. Genome …

Combinatorial patterns of epigenetic features reflect transcriptional states and functions of
genomic regions. While many epigenetic features have correlated relationships, most …

Background Epigenetic modification of chromatin plays a pivotal role in regulating gene
expression during cell differentiation. The scale and complexity of epigenetic data pose …

Knowledge of locations and activities of cis-regulatory elements (CREs) is needed to
decipher basic mechanisms of gene regulation and to understand the impact of genetic …

A large-scale application of the “stacked modeling” approach for chromatin state discovery
previously provides a single “universal” chromatin state annotation of the human genome …

Motivation Automated chromatin segmentation based on ChIP-seq (chromatin
immunoprecipitation followed by sequencing) data reveals insights into the epigenetic …

Various computational approaches have been developed to annotate epigenomes on a per-
position basis by modeling combinatorial and spatial patterns within epigenomic data …

Motivation Genome-wide maps of epigenetic modifications are powerful resources for non-
coding genome annotation. Maps of multiple epigenetics marks have been integrated into …