During the past century, few proteins have matched erythropoietin (Epo) in capturing the
imagination of physiologists, molecular biologists, and, more recently, physicians and …

Although debated for many years whether haemodynamic or structural changes are more
important in the development of diabetic nephropathy, it is now clear that these processes …

Hyperglycemia results in increased oxygen consumption and decreased oxygen tension in
the kidney. We tested the hypothesis that activation of hypoxia-inducible factors (HIFs) …

Role of hypoxia in the pathogenesis of renal disease The kidney shows a remarkable
discrepancy between blood supply and oxygenation. Despite high blood flow and oxygen …

A greatly expanded understanding of the biology of endogenous erythropoietin (EPO) has
emerged since the early 1990s. Originally viewed as the renal hormone dedicated to …

Renal ischemia-reperfusion (IR) contributes to the development of ischemic acute renal
failure (ARF). Multi-factorial processes are involved in the development and progression of …

Interest in the diverse biology of protein tyrosine phosphatases that are encoded by more
than 100 genes in the human genome continues to grow at an accelerated pace. In …

Objectives: We assessed the effects of erythropoietin (EPO) treatment in a rat model of post-
myocardial infarction (MI) heart failure. Background: Erythropoietin, traditionally known as a …

Renal parenchymal hypoxia, documented under a variety of clinical conditions, conceivably
contributes to the progression chronic kidney disease. In this review, normal physiologic …

Aims Erythropoietin (EPO) improves cardiac function and induces neovascularization in
chronic heart failure (CHF), although the exact mechanism has not been elucidated. We …