Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

The formation of amyloid fibrils is a general class of protein self-assembly behaviour, which
is associated with both functional biology and the development of a number of disorders …

Oligomers which form during amyloid fibril assembly are considered to be key contributors
towards amyloid disease. However, understanding how such intermediates form, their …

Abrupt aggregation of amyloid β1‐42 (Aβ) peptide is a hallmark of Alzheimer's disease (AD),
a severe pathology that affects more than 44 million people worldwide. A growing body of …

Amyloid formation is a hallmark of many medical diseases including diabetes type 2,
Alzheimer's and Parkinson diseases. Under these pathological conditions, misfolded …

Lipid bilayers play an important role in the pathological assembly of amyloidogenic proteins
and peptides. This assembly yields oligomers and fibrils, which are highly toxic protein …

Phosphatidylserine (PS) in the plasma membrane plays an important role in cell signaling
and apoptosis. Cell degeneration is also linked to numerous amyloid diseases, pathologies …

Abrupt aggregation of misfolded proteins is a hallmark of a large number of severe
pathologies, including diabetes types 1 and 2, Alzheimer, and Parkinson diseases. A …

Phosphatidic acid (PA) is a unique plasma membrane lipid that contains fatty acids (FAs)
with different lengths and degrees of unsaturation. Under physiological conditions, PA acts …

Mutations in the SNCA gene, which encodes the protein α-synuclein, have been linked with
early onset Parkinson's disease. The exact nature of this association, however, is still poorly …