The role of inflammation in the development of epilepsy

A Rana, AE Musto - Journal of neuroinflammation, 2018 - Springer
Epilepsy, a neurological disease characterized by recurrent seizures, is often associated
with a history of previous lesions in the nervous system. Impaired regulation of the activation …

Manipulation of innate and adaptive immunity by staphylococcal superantigens

SW Tuffs, SMM Haeryfar, JK McCormick - Pathogens, 2018 - mdpi.com
Staphylococcal superantigens (SAgs) constitute a family of potent exotoxins secreted by
Staphylococcus aureus and other select staphylococcal species. SAgs function to cross-link …

Superantigens and SARS-CoV-2

A Hamdy, A Leonardi - Pathogens, 2022 - mdpi.com
It has been posited SARS-CoV-2 contains at least one unique superantigen-like motif not
found in any other SARS or endemic coronaviruses. Superantigens are potent antigens that …

The role of interferons in Long COVID infection

M Karbalaeimahdi, S Farajnia, N Bargahi… - Journal of Interferon & …, 2023 - liebertpub.com
Although the new generation of vaccines and anti-COVID-19 treatment regimens facilitated
the management of acute COVID-19 infections, concerns about post-COVID-19 syndrome or …

Novel insights into the immune response to bacterial T cell superantigens

SW Tuffs, K Dufresne, A Rishi, NR Walton… - Nature Reviews …, 2024 - nature.com
Bacterial T cell superantigens (SAgs) are a family of microbial exotoxins that function to
activate large numbers of T cells simultaneously. SAgs activate T cells by direct binding and …

Streptococcal pharyngitis and rheumatic heart disease: the superantigen hypothesis revisited

JR Hurst, KJ Kasper, AN Sule, JK McCormick - Infection, Genetics and …, 2018 - Elsevier
Streptococcus pyogenes is a human-specific and globally prominent bacterial pathogen that
despite causing numerous human infections, this bacterium is normally found in an …

Cellular and molecular mechanisms of autoimmunity and lupus nephritis

SK Devarapu, G Lorenz, OP Kulkarni, HJ Anders… - International review of …, 2017 - Elsevier
Autoimmunity involves immune responses directed against self, which are a result of
defective self/foreign distinction of the immune system, leading to proliferation of self …

Blocking Superantigen‐Mediated Diseases: Challenges and Future Trends

P Wang, Z Fredj, H Zhang, G Rong… - Journal of …, 2024 - Wiley Online Library
Superantigens are virulence factors secreted by microorganisms that can cause various
immune diseases, such as overactivating the immune system, resulting in cytokine storms …

The association between C509T, T869C, G915C gene polymorphisms of transforming growth factor-β1 and systemic lupus erythematosus risk: A meta-analysis

N Chen, Y Dai, J He, M Zhou, H Sun, L Lin, F Gao… - Medicine, 2023 - journals.lww.com
Background: The relationship between transforming growth factor-β1 (TGF-β1) gene
polymorphisms and systemic lupus erythematosus (SLE) has been reported in many …

Роль инфекций в развитии аутоиммунных заболеваний

ОВ Москалец - Казанский медицинский журнал, 2017 - cyberleninka.ru
С момента открытия феномена иммунологической толерантности не прекращается
активное обсуждение роли генетических факторов и факторов внешней среды в …