Maintenance of Na+ and K+ gradients across the cell plasma membrane is an essential
process for mammalian cell survival. An enzyme responsible for this process, sodium …

Cardiac glycosides (CGs) are natural compounds widely used in the treatment of several
cardiac conditions and more recently have been recognized as potential antitumor …

Recent advances in DNA/RNA sequencing have made it possible to identify new targets
rapidly and to repurpose approved drugs for treating heterogeneous diseases by the …

Ion channels are key regulators of cancer cell pathophysiology. They contribute to a variety
of processes such as maintenance of cellular osmolarity and membrane potential, motility …

Cardiotonic steroids (CTS) were first documented by ancient Egyptians more than 3000
years ago. Cardiotonic steroids are a group of steroid hormones that circulate in the blood of …

Natriuretic hormones (NH) include three groups of compounds: the natriuretic peptides
(ANP, BNP and CNP), the gastrointestinal peptides (guanylin and uroguanylin), and …

Background The Na+/K+-ATPase (NKP) is an important ion transporter also involved in
signal transduction. Its expression profile is altered in various tumours including that of the …

Since the discovery of ouabain as a cardiotonic steroid hormone present in higher
mammals, research about it has progressed rapidly and several of its physiological and …

Helicates and related metallofoldamers, synthesised by dynamic self-assembly, represent
an area of chemical space inaccessible by traditional organic synthesis, and yet with …

The ion pump Na+, K+–ATPase (NKA) is a receptor for the cardiotonic steroid ouabain.
Subsaturating concentration of ouabain triggers intracellular calcium oscillations, stimulates …