In this comprehensive review, we examine the main preclinical and clinical investigations
assessing the effects of different forms of choline supplementation currently available …

The roles of choline and of choline-containing phospholipids (CCPLs) on the maintenance
and progress of neurovascular unit (NVU) integrity are analyzed. NVU is composed of …

Identifying the health benefits of phytochemicals is an essential step in drug and functional
food development. While many in vitro screening methods have been developed to identify …

Vascular cognitive impairment dementia (VCID), which is an increasingly important cause of
dementia in the elderly, lacks effective treatments. Many different types of vascular disease …

Choline participates in several relevant neurochemical processes. It is the precursor and
metabolite of acetylcholine (ACh), plays a role in single-carbon metabolism and is an …

Alzheimer's disease (AD) is the most common cause of dementia worldwide. Because
Alzheimer's disease has no known treatment, sufferers and their caregivers must …

Cholinergic precursors have represented the first approach to counter cognitive impairment
occurring in adultonset dementia disorders. These compounds were early leaved because …

Vascular cognitive impairment (VCI) refers to the entire spectrum of vascular brain
pathologies that contribute to cognitive deficits, ranging from subjective cognitive decline to …

Arterial hypertension is the main risk factor for stroke and plays a role in the development of
vascular cognitive impairment (VCI) and vascular dementia (VaD). An association between …

Background: Citicoline can have beneficial effects both in degenerative and in vascular
cognitive decline in a variety of ways (apoptosis inhibition, neuroplasticity potentiation …