In metazoan cell nuclei, hundreds of large chromatin domains are in close contact with the
nuclear lamina. Such lamina-associated domains (LADs) are thought to help organize …

Abstract The Myogenic Regulatory Factors (MRFs) Myf5, MyoD, myogenin and MRF4 are
members of the basic helix-loop-helix family of transcription factors that control the …

At the nuclear periphery, associations of chromatin with the nuclear lamina through lamina-
associated domains (LADs) aid functional organization of the genome. We review the …

Eukaryotic cells have a layer of heterochromatin at the nuclear periphery. To investigate
mechanisms regulating chromatin distribution, we analyzed heterochromatin organization in …

Nuclear organization has been implicated in regulating gene activity. Recently, large
developmentally regulated regions of the genome dynamically associated with the nuclear …

Gene regulation relies on transcription factors (TFs) exploring the nucleus searching their
targets. So far, most studies have focused on how fast TFs diffuse, underestimating the role …

Chronic inflammation due to obesity contributes to the development of metabolic diseases,
autoimmune diseases, and cancer. Reciprocal interactions between metabolic systems and …

The resolution of a microscope is determined by the diffraction limit in classical microscopy,
whereby objects that are separated by half a wavelength can no longer be visually …

Lamins interact with a host of nuclear membrane proteins, transcription factors, chromatin
regulators, signaling molecules, splicing factors, and even chromatin itself to form a nuclear …

Deciphering the molecular basis of pluripotency is fundamental to our understanding of
development and embryonic stem cell function. Here, we report that TAF3, a TBP-associated …