Multiple pathophysiological roles of midkine in human disease

Y Cai, Y Lv, Z Mo, J Lei, J Zhu, Q Zhong - Cytokine, 2020 - Elsevier
Midkine (MK) is a low molecular-weight protein that was first identified as the product of a
retinoic acid-responsive gene involved in embryonic development. Recent studies have …

Spermidine-eugenol supplement preserved inflammation-challenged intestinal cells by stimulating autophagy

F Truzzi, A Whittaker, E D'Amen, MC Valerii… - International Journal of …, 2023 - mdpi.com
Increases in non-communicable and auto-immune diseases, with a shared etiology of
defective autophagy and chronic inflammation, have motivated research both on natural …

Overexpression and potential roles of midkine via regulation of vascular endothelial growth factor A in psoriasis

L Li, H Shucheng, L Fu, B Pei, W Xu… - Experimental …, 2023 - Wiley Online Library
Midkine plays a critical role in angiogenesis by regulating the vascular endothelial growth
factor (VEGF) signalling pathway, which is known to be associated with psoriasis …

Identification of Key Genes in Fetal Gut Development at Single‐Cell Level by Exploiting Machine Learning Techniques

QL Ma, M Meng, XC Zhou, W Guo, KY Feng… - …, 2024 - Wiley Online Library
The study of fetal gut development is critical due to its substantial influence on immediate
neonatal and long‐term adult health. Current research largely focuses on microbiome …

Relationship between serum Midkine and Omentin-1 levels and the severity of sepsis in patients and their prognostic value

L Gao, Q Liu, Z Kuang, S Yuan - Libyan Journal of Medicine, 2024 - Taylor & Francis
To explore the relationship between serum levels of midkine and omentin-1 and the severity
of sepsis in patients, and their prognostic value. A retrospective analysis was conducted on …

Basic Three-Dimensional (3D) Intestinal Model System with an Immune Component

F Truzzi, S Dilloo, X Chang, A Whittaker… - JoVE (Journal of …, 2023 - jove.com
There has been an increase in the use of in vivo and in vitro intestinal models to study the
pathophysiology of inflammatory intestinal diseases, for the pharmacological screening of …

Author Spotlight: Investigating the Effects of Compounds on Intestinal Tissue Using 3D Human Cell Line Models

F Truzzi, S Dilloo, X Chang, A Whittaker… - JoVE (Journal of …, 2023 - jove.com
There has been an increase in the use of in vivo and in vitro intestinal models to study the
pathophysiology of inflammatory intestinal diseases, for the pharmacological screening of …

Evaluation of serum midkine levels and metabolic parameters in patients with hidradenitis suppurativa

HH Ayvaz Çelik, S Korkmaz - Archives of Dermatological Research, 2023 - Springer
The exact pathogenesis of Hidradenitis suppurativa (HS) has not been known yet. Midkine
(MK) is a heparin-binding protein that has crucial roles in many processes such as cell …

Serum-soluble receptor for advanced glycation end-products values might have diagnostic and prognostic significances in ulcerative colitis

İ Küçük, E Tural, Y Yazgan, BÇ Güney… - Journal of Health …, 2023 - dergipark.org.tr
Aims: There is evidence of anti-inflammatory qualities associated with a soluble receptor for
advanced glycation end products (sRAGE). We aimed to evaluate whether serum sRAGE …

A Review Of Midkine As Biomarker Protein For Diagnostic Several Dieases

MM Jawad, AH Hussein - Medical …, 2022 - medical.science.journal-asia …
Background: This review deals with a collection of information about a protein marker that is
very important and alternates presence in many cases of normal and pathological growth, as …