Molecular Actions of PPARα in Lipid Metabolism and Inflammation
N Bougarne, B Weyers, SJ Desmet, J Deckers… - Endocrine …, 2018 - academic.oup.com
Peroxisome proliferator–activated receptor α (PPAR α) is a nuclear receptor of clinical
interest as a drug target in various metabolic disorders. PPAR α also exhibits marked anti …
interest as a drug target in various metabolic disorders. PPAR α also exhibits marked anti …
PPARs in obesity-induced T2DM, dyslipidaemia and NAFLD
Obesity is a worldwide epidemic that predisposes individuals to cardiometabolic
complications, such as type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease …
complications, such as type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease …
[HTML][HTML] Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease
Peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription
factor belonging, together with PPARγ and PPARβ/δ, to the NR1C nuclear receptor …
factor belonging, together with PPARγ and PPARβ/δ, to the NR1C nuclear receptor …
The role and regulation of the peroxisome proliferator activated receptor alpha in human liver
S Kersten, R Stienstra - Biochimie, 2017 - Elsevier
The peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription
factor that is abundantly expressed in liver. PPARα is activated by fatty acids and various …
factor that is abundantly expressed in liver. PPARα is activated by fatty acids and various …
Dynamic role of the transmembrane glycoprotein CD36 (SR-B2) in cellular fatty acid uptake and utilization
JFC Glatz, JJFP Luiken - Journal of lipid research, 2018 - ASBMB
The widely expressed transmembrane glycoprotein, cluster of differentiation 36 (CD36), a
scavenger receptor class B protein (SR-B2), serves many functions in lipid metabolism and …
scavenger receptor class B protein (SR-B2), serves many functions in lipid metabolism and …
[HTML][HTML] PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation
Cells are constantly exposed to a large variety of lipids. Traditionally, these molecules were
thought to serve as simple energy storing molecules. More recently it has been realized that …
thought to serve as simple energy storing molecules. More recently it has been realized that …
Regulation of lipid metabolism by the unfolded protein response
The endoplasmic reticulum (ER) is the site of protein folding and secretion, Ca2+ storage
and lipid synthesis in eukaryotic cells. Disruption to protein folding or Ca2+ homeostasis in …
and lipid synthesis in eukaryotic cells. Disruption to protein folding or Ca2+ homeostasis in …
The mechanisms of action of PPARs
J Berger, DE Moller - Annual review of medicine, 2002 - annualreviews.org
▪ Abstract The peroxisome proliferator-activated receptors (PPARs) are a group of three
nuclear receptor isoforms, PPARγ, PPARα, and PPARδ, encoded by different genes. PPARs …
nuclear receptor isoforms, PPARγ, PPARα, and PPARδ, encoded by different genes. PPARs …
Perfluoroalkyl acids: a review of monitoring and toxicological findings
C Lau, K Anitole, C Hodes, D Lai… - Toxicological …, 2007 - academic.oup.com
In recent years, human and wildlife monitoring studies have identified perfluoroalkyl acids
(PFAA) worldwide. This has led to efforts to better understand the hazards that may be …
(PFAA) worldwide. This has led to efforts to better understand the hazards that may be …
Peroxisome proliferator‐activated receptor alpha target genes
The peroxisome proliferator‐activated receptor alpha (PPARα) is a ligand‐activated
transcription factor involved in the regulation of a variety of processes, ranging from …
transcription factor involved in the regulation of a variety of processes, ranging from …