Targeting RNA for processing or destruction by the eukaryotic RNA exosome and its cofactors
The eukaryotic RNA exosome is an essential and conserved protein complex that can
degrade or process RNA substrates in the 3′-to-5′ direction. Since its discovery nearly …
degrade or process RNA substrates in the 3′-to-5′ direction. Since its discovery nearly …
RNA Degradation in Saccharomyces cerevisae
R Parker - Genetics, 2012 - academic.oup.com
All RNA species in yeast cells are subject to turnover. Work over the past 20 years has
defined degradation mechanisms for messenger RNAs, transfer RNAs, ribosomal RNAs …
defined degradation mechanisms for messenger RNAs, transfer RNAs, ribosomal RNAs …
Translation drives mRNA quality control
CJ Shoemaker, R Green - Nature structural & molecular biology, 2012 - nature.com
There are three predominant forms of co-translational mRNA surveillance: nonsense-
mediated decay (NMD), no-go decay (NGD) and nonstop decay (NSD). Although discussion …
mediated decay (NMD), no-go decay (NGD) and nonstop decay (NSD). Although discussion …
The enzymes and control of eukaryotic mRNA turnover
The degradation of eukaryotic mRNAs plays important roles in the modulation of gene
expression, quality control of mRNA biogenesis and antiviral defenses. In the past five years …
expression, quality control of mRNA biogenesis and antiviral defenses. In the past five years …
Interaction profiling identifies the human nuclear exosome targeting complex
M Lubas, MS Christensen, MS Kristiansen… - Molecular cell, 2011 - cell.com
The RNA exosome is a conserved degradation machinery, which obtains full activity only
when associated with cofactors. The most prominent activator of the yeast nuclear exosome …
when associated with cofactors. The most prominent activator of the yeast nuclear exosome …
AU binding proteins recruit the exosome to degrade ARE-containing mRNAs
Inherently unstable mammalian mRNAs contain AU-rich elements (AREs) within their 3′
untranslated regions. Although found 15 years ago, the mechanism by which AREs dictate …
untranslated regions. Although found 15 years ago, the mechanism by which AREs dictate …
Exosome-mediated recognition and degradation of mRNAs lacking a termination codon
A Van Hoof, PA Frischmeyer, HC Dietz, R Parker - Science, 2002 - science.org
One role of messenger RNA (mRNA) degradation is to maintain the fidelity of gene
expression by degrading aberrant transcripts. Recent results show that mRNAs without …
expression by degrading aberrant transcripts. Recent results show that mRNAs without …
RNA-quality control by the exosome
The exosome complex of 3′→ 5′ exonucleases is an important component of the RNA-
processing machinery in eukaryotes. This complex functions in the accurate processing of …
processing machinery in eukaryotes. This complex functions in the accurate processing of …
Nuclear surveillance and degradation of hypomodified initiator tRNAMet in S. cerevisiae
S Kadaba, A Krueger, T Trice, AM Krecic… - Genes & …, 2004 - genesdev.cshlp.org
The tRNA m1A58 methyltransferase is composed of two subunits encoded by the essential
genes TRM6 and TRM61 (formerly GCD10 and GCD14). The trm6-504 mutation results in a …
genes TRM6 and TRM61 (formerly GCD10 and GCD14). The trm6-504 mutation results in a …
Spo11 and the formation of DNA double-strand breaks in meiosis
S Keeney - Recombination and meiosis: crossing-over and …, 2007 - Springer
Meiotic recombination is carried out through a specialized pathway for the formation and
repair of DNA double-strand breaks made by the Spo11 protein, a relative of archaeal …
repair of DNA double-strand breaks made by the Spo11 protein, a relative of archaeal …