Cells of myeloid origin, such as microglia and macrophages, act at the crossroads of several
inflammatory mechanisms during pathophysiology. Besides pro-inflammatory activity (M1 …

The peroxisome proliferator-activated receptors, PPARα, PPARβ, and PPARγ, are a family of
transcription factors activated by a diversity of molecules including fatty acids and fatty acid …

Nuclear receptors, also known as ligand-activated transcription factors, regulate gene
expression upon ligand signals and present as attractive therapeutic targets especially in …

In recent years neurodevelopmental problems in children have increased at a rate that
suggests lifestyle factors and chemical exposures as likely contributors. When …

Astrocyte-mediated inflammation is associated with degenerative pathologies such as
Alzheimer's and Parkinson's diseases and multiple sclerosis. The acute inflammation and …

Peroxisome proliferator-activated receptor (PPAR)-β/δ is a member of the PPAR nuclear
hormone receptor family. The PPARs are a family of 3 ligand-activated transcription factors …

The beneficial effects of exercise on the proper functioning of the body have been firmly
established. Multi-systemic metabolic regulation of exercise is the consequence of …

There is increasing evidence that an active lifestyle benefits both body and brain. However,
not everyone may be able to exercise due to disease, injury or aging-related frailty …

Peroxisome proliferator‐activated receptors (PPARs) are ligand‐activated transcription
factors that play pivotal roles in the regulation of a very large number of biological processes …

Lipoxygenase (12/15-LO) is an enzyme that converts polyunsaturated fatty acids into
bioactive lipid derivatives. In this study, we showed that inhibition of 12/15-LO by baicalein …