Neurological and mental illnesses account for a considerable proportion of the global
burden of disease. Exercise has many beneficial effects on brain health, contributing to …

Skeletal muscle has recently been identified as an endocrine organ. It has, therefore, been
suggested that cytokines and other peptides that are produced, expressed, and released by …

Regular exercise offers protection against all-cause mortality, primarily by protection against
cardiovascular disease and Type 2 diabetes mellitus. The latter disorders have been …

It is now recognized that contracting skeletal muscle may synthesize and release interleukin-
6 (IL-6) into the interstitium as well as into the systemic circulation in response to a bout of …

Eccentric exercise commonly results in muscle damage. The primary sequence of events
leading to exercise-induced muscle damage is believed to involve initial mechanical …

Muscle specific miRNAs, myomiRs, have been shown to control muscle development in vitro
and are differentially expressed at rest in diabetic skeletal muscle. Therefore, we …

Some of the most serious consequences of ageing are its effects on skeletal muscle. The
term 'sarcopenia'describes the slow but progressive loss of muscle mass with advancing …

It has been recognized for some time that cardiovascular disease and type 2 diabetes are, to
a major extent, inflammatory disorders associated with an environment characterized by a …

Regular exercise offers protection against all cause mortality and there is evidence from
randomised intervention studies that physical training is effective as a treatment in patients …

Cancer cachexia is a debilitating consequence of disease progression, characterised by the
significant weight loss through the catabolism of both skeletal muscle and adipose tissue …