Pharmaceutical agents, drugs of abuse, and toxic substances have a large impact, positive
and negative, on modern society. Efforts to mitigate the side effects of pharmaceuticals and …

This article traces the development of acyclic cucurbit [n] uril‐type receptors with a focus on
work from the Isaacs group. First, we describe the synthesis of methylene bridged glycoluril …

The history of ketamine begins in the 1950s at Parke-Davis and Company's laboratories in
Detroit, Michigan, USA. At that time, Parke-Davis were searching among cyclohexylamines …

Current management of anesthesia‐associated complications falls short in terms of both
efficacy and safety. Nanomaterials with versatile properties and unique nano‐bio …

We measured the affinity of five molecular container compounds (calabadions 1 and 2, CB
[7], sulfocalix [4] arene, and HP‐β‐CD) toward seven drugs of abuse in homogenous …

Succinylcholine (Sch) is the only depolarizing neuromuscular blocking agent widely used for
rapid sequence induction in emergency rooms. Unfortunately, a variety of (sometimes lethal) …

Abstract Background We hypothesised that Calabadion 1, an acyclic cucurbit [n] uril
molecular container, reverses fentanyl-induced respiratory depression and dysfunction of …

Opioids may produce life-threatening respiratory depression and death from their actions at
the opioid receptors within the brainstem respiratory neuronal network. Since there is an …

We report investigations of the use of cucurbit [8] uril (CB [8]) macrocycles as an antidote to
counteract the in vivo biological effects of phencyclidine. We investigate the binding of CB [8] …

Cyclodextrins (CDs) have been previously shown to display modest equilibrium binding
affinities (K a~ 100–200 M-1) for the synthetic opioid analgesic fentanyl. In this work, we …