Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …

Thioamidation as a posttranslational modification is exceptionally rare, with only a few
reported natural products and exactly one known protein example (methyl-coenzyme M …

Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a growing
family of natural products with diverse activities and structures. RiPP classes are defined by …

The past decade has seen impressive advances in understanding the biosynthesis of
ribosomally synthesized and posttranslationally modified peptides (RiPPs). One of the most …

The rational discovery of new specialized metabolites by genome mining represents a very
promising strategy in the quest for new bioactive molecules. Ribosomally synthesized and …

Thiopeptides are members of the ribosomally synthesized and post-translationally modified
peptide family of natural products. Most characterized thiopeptides display nanomolar …

Methyl-coenzyme M reductase (MCR) catalyzes the methane-forming step in methanogenic
archaea. The active enzyme harbors the nickel (I) hydrocorphin coenzyme F-430 as a …

The ribosomally synthesized and post-translationally modified peptide (RiPPs) class of
natural products has undergone significant expansion due to the rapid growth in genome …

Graspetides are a class of ribosomally synthesized and post-translationally modified peptide
natural products featuring ATP-grasp ligase-dependent formation of macrolactones …

Exploration of the full potential of thioamide substitution as a tool in the chemical biology of
peptides and proteins has been hampered by insufficient synthetic strategies for the site …