A comprehensive review of mRNA vaccines

V Gote, PK Bolla, N Kommineni, A Butreddy… - International journal of …, 2023 - mdpi.com
mRNA vaccines have been demonstrated as a powerful alternative to traditional
conventional vaccines because of their high potency, safety and efficacy, capacity for rapid …

Self-assembled mRNA vaccines

J Kim, Y Eygeris, M Gupta, G Sahay - Advanced drug delivery reviews, 2021 - Elsevier
Abstract mRNA vaccines have evolved from being a mere curiosity to emerging as COVID-
19 vaccine front-runners. Recent advancements in the field of RNA technology, vaccinology …

The mRNA vaccine revolution: COVID-19 has launched the future of vaccinology

Z Ye, J Harmon, W Ni, Y Li, D Wich, Q Xu - ACS nano, 2023 - ACS Publications
During the COVID-19 pandemic, mRNA (mRNA) vaccines emerged as leading vaccine
candidates in a record time. Nonreplicating mRNA (NRM) and self-amplifying mRNA (SAM) …

mRNA-based vaccines and therapeutics: An in-depth survey of current and upcoming clinical applications

YS Wang, M Kumari, GH Chen, MH Hong… - Journal of Biomedical …, 2023 - Springer
Abstract mRNA-based drugs have tremendous potential as clinical treatments, however, a
major challenge in realizing this drug class will promise to develop methods for safely …

Cap 1 Messenger RNA Synthesis with Co‐transcriptional CleanCap® Analog by In Vitro Transcription

JM Henderson, A Ujita, E Hill… - Current …, 2021 - Wiley Online Library
Synthetic messenger RNA (mRNA)− based therapeutics are an increasingly popular
approach to gene and cell therapies, genome engineering, enzyme replacement therapy …

Chemical modifications of mRNA ends for therapeutic applications

M Warminski, A Mamot, A Depaix… - Accounts of Chemical …, 2023 - ACS Publications
Conspectus Messenger ribonucleic acid (mRNA) is the universal cellular instruction for
ribosomes to produce proteins. Proteins are responsible for most of the functions of living …

mRNA vaccines: The future of prevention of viral infections?

P Rzymski, A Szuster‐Ciesielska… - Journal of medical …, 2023 - Wiley Online Library
Messenger RNA (mRNA) vaccines against COVID‐19 are the first authorized biological
preparations developed using this platform. During the pandemic, their administration has …

Roles of RNA methylation on tumor immunity and clinical implications

M Zhang, J Song, W Yuan, W Zhang, Z Sun - Frontiers in immunology, 2021 - frontiersin.org
RNA methylation is a kind of RNA modification that exists widely in eukaryotes and
prokaryotes. RNA methylation occurs not only in mRNA but also in ncRNA. According to the …

Nanomedicine-based approaches for mRNA delivery

S Uchida, F Perche, C Pichon… - Molecular …, 2020 - ACS Publications
Messenger RNA (mRNA) has immense potential for developing a wide range of therapies,
including immunotherapy and protein replacement. As mRNA presents no risk of integration …

Non-immunotherapy application of LNP-mRNA: Maximizing efficacy and safety

I Vlatkovic - Biomedicines, 2021 - mdpi.com
Lipid nanoparticle (LNP) formulated messenger RNA-based (LNP-mRNA) vaccines came
into the spotlight as the first vaccines against SARS-CoV-2 virus to be applied worldwide …