Summary Mycobacterium bovis bacille Calmette-Guérin (BCG), an experimental vaccine
designed to protect cattle from bovine tuberculosis, was administered for the first time to a …

Patients with autosomal recessive (AR) IL-12p40 or IL-12Rβ1 deficiency display Mendelian
susceptibility to mycobacterial disease (MSMD) due to impaired IFN-γ production and, less …

The innate immune system is the host's first line of defense against pathogens. Toll-like
receptors (TLRs) are pattern recognition receptors that mediate recognition of pathogen …

Mendelian susceptibility to mycobacterial disease (MSMD) arises from a group of rare
inherited errors of immunity that result in selective susceptibility of otherwise healthy people …

Mendelian susceptibility to mycobacterial disease (MSMD) is a rare genetic disorder
characterized by impaired immunity against intracellular pathogens, such as mycobacteria …

In medical mycology, the main context of disease is iatrogenic-based disease. However,
historically, and occasionally, even today, fungal diseases affect humans with no obvious …

Purpose Inborn errors of immunity (IEI) are typically monogenic. Data from the Indian
subcontinent are relatively scarce. This paper evaluates IEI diagnosed in Sri Lanka …

Background Patients with Mendelian susceptibility to mycobacterial disease (MSMD)
experience recurrent and/or persistent infectious diseases associated with poorly virulent …

Background Mycobacteria include ubiquitous species of varying virulence. However,
environmental and individual-specific factors, particularly host genetics, play a crucial role in …

Inborn errors of immunity (IEI) are genetic disorders with extensive clinical presentations.
They can range from increased susceptibility to infections to significant immune …