Pro-inflammatory systemic conditions that can cause neuroinflammation and subsequent
alterations in brain regions involved in emotional regulation have been suggested as an …

The differences in cognitive processes driven by biological sex are the issues that have
gotten growing attention recently. Considering the increasing population suffering from …

Background Chronic stress–induced inflammatory responses occur in part via danger-
associated molecular pattern (DAMP) molecules, such as high mobility group box 1 protein …

The present study aimed to review major depression, including its types, epidemiology,
association with different diseases status and treatments, as well as its correlation with the …

Depression is a highly prevalent and debilitating condition, only partially addressed by
current pharmacotherapies. The lack of response to treatment by many patients prompts the …

Traditional knowledge can be used as a source for development of new medicines. In the
present study, we compare the data on saffron in Razi's Al-Hawi book with modern scientific …

Major Depressive Disorder (MDD) is the most common psychiatric disease, affecting millions
of people worldwide. In addition to the well-defined depressive symptoms, patients suffering …

Agomelatine is a selective agonist of melatonin receptor 1A/melatonin receptor 1B (MT 1/MT
2) and antagonist of 5-hydroxytryptamine 2C receptors. It is used clinically to treat major …

Brain-derived neurotrophic factor (BDNF) is a neurotrophin that serves as a survival factor
for neurons. Agomelatine is a novel antidepressant as well as a potent agonist of melatonin …

Background: Agomelatine modulates brain-derived neurotrophic factor expression via its
interaction with melatonergic and serotonergic receptors and has shown promising results in …