In recent years, environmental and economic reasons have motivated the development of
transition metal‐free carbon‐carbon bond forming reactions and some excellent reviews …

Background: Hypertension is a risk factor for renal disease. Therefore, this study was aimed
at estimating the prevalence of hypertension in renal patients in Iran through meta-analysis …

The new alkaloids marinacarbolines E–Q (1–10, 12–14), caerulomycin N (15), and
actinoallonaphthyridine A (16), together with the known marinacarboline C (11) and …

Nuclear receptors are a unique family of transcription factors that play cardinal roles in
physiology and plethora of human diseases. The adopted orphan nuclear receptor Nr1d1 is …

We have recently demonstrated that Caerulomycin A induces regulatory T cells
differentiation by suppressing Th1 cells activity. The role of regulatory T cells is well …

Purpose To elucidate the therapeutic potential of 2, 2'-bipyridine derivatives [NPS (1–6)] on
hepatocellular carcinoma HepG2 cells. Methods The effects on cell survival, colony …

Caerulomycin A (CRM A 1) belongs to a family of natural products containing a 2, 2′-
bipyridyl ring core structure and is currently under development as a potent novel …

Caerulomycins are a family of natural alkaloids featuring a 2, 2′-bipyridine nucleus. Since
the first example of caerulomycins, caerulomycin A from Streptomyces caeruleus, was …

In this study, we characterized CaeB6 as a selective hydroxylase and CaeG1 as an O-
methyltransferase in the biosynthesis of the 2, 2′-bipyridine natural products caerulomycins …

Here, we report a two-component enzymatic system that efficiently catalyzes the reduction of
a carboxylate to an aldehyde in the biosynthesis of 2, 2′-bipyridine antibiotics …