Publisher Summary The term “acute phase” was introduced by Avery and his colleagues to
refer to serum obtained from patients who were acutely ill with infectious disease, containing …

The pentraxins are an ancient family of proteins with a unique architecture found as far back
in evolution as the Horseshoe crab. In humans the two members of this family are C‐reactive …

Background The amyloid fibril deposits that cause systemic amyloidosis always contain the
nonfibrillar normal plasma protein, serum amyloid P component (SAP). The drug (R)-1-[6 …

The discovery of C-reactive protein (CRP) half a century ago led to the description of the
acute-phase reaction which is a fundamental response of the body to injury. Recent work on …

Accumulation of amyloid fibrils in the viscera and connective tissues causes systemic
amyloidosis, which is responsible for about one in a thousand deaths in developed …

The three-dimensional structure of pentameric human serum amyloid P component at high
resolution, the first reported for a pentraxin, reveals that the tertiary fold is remarkably similar …

Wound healing and the dysregulated events leading to fibrosis both involve the proliferation
and differentiation of fibroblasts and the deposition of extracellular matrix. Whether these …

Fibronectin is a major protein of blood and tissues. It has been intensively studied because
of its many interactions with cells and other macromolecules. Fibronectin is a principal …

Pentraxin 3 (PTX3) is a fluid-phase pattern recognition molecule and a key component of the
humoral arm of innate immunity. In four different models of tissue damage in mice, PTX3 …

Amyloid P component (AP) is a glycoprotein derived from, and identical to, the normal
circulating plasma glycoprotein, serum amyloid P component (SAP). AP is present in all …