Diabetic neuropathy is regarded as one of the most debilitating outcomes of diabetes
mellitus and may cause pain, decreased motility, and even amputation. Diabetic neuropathy …

Background The molecular nature of lipoic acid (LA) clarifies its capability of taking part to a
variety of biochemical reactions where redox state is meaningful. The pivotal action of LA is …

1. Lipoic acid is an example of an existing drug whose therapeutic effect has been related to
its antioxidant activity. 2. 2. Antioxidant activity is a relative concept: it depends on the kind of …

Diabetic complications are the major cause of morbidity and mortality in persons with
diabetes. Chronic hyperglycemia is a major initiator of diabetic microvascular complications …

This review summarises the results and discussions of an UNESCO‐MCBN supported
symposium on oxidative stress and its role in the onset and progression of diabetes. There is …

Diabetes mellitus is a major cause of peripheral neuropathy, commonly manifested as distal
symmetrical polyneuropathy. This review examines evidence for the importance of vascular …

Aims To determine the efficacy and safety of 600 mg of α‐lipoic acid given intravenously
over 3 weeks in diabetic patients with symptomatic polyneuropathy. Methods We searched …

OBJECTIVE—The aim of this trial was to evaluate the effects of α-lipoic acid (ALA) on
positive sensory symptoms and neuropathic deficits in diabetic patients with distal symmetric …

α-Lipoic acid (LA) and its reduced form, dihydrolipoic acid, are powerful antioxidants. LA
scavenges hydroxyl radicals, hypochlorous acid, peroxynitrite, and singlet oxygen …

Anti-oxidant treatment has been shown to prevent nerve dysfunction in experimental
diabetes mellitus, thus providing a rationale of potential therapeutic value for diabetic …