Combination of light and Ru (II) polypyridyl complexes: Recent advances in the development of new anticancer drugs

L Conti, E Macedi, C Giorgi, B Valtancoli… - Coordination Chemistry …, 2022 - Elsevier
The increasing impact of cancer on worldwide mortality makes the research of novel
chemotherapeutic agents a current and challenging issue. In the recent years, transition …

Rationally designed long-wavelength absorbing Ru (II) polypyridyl complexes as photosensitizers for photodynamic therapy

J Karges, F Heinemann, M Jakubaszek… - Journal of the …, 2020 - ACS Publications
The utilization of photodynamic therapy (PDT) for the treatment of various types of cancer
has gained increasing attention over the last decades. Despite the clinical success of …

Factors that influence singlet oxygen formation vs. ligand substitution for light-activated ruthenium anticancer compounds

ET Papish, OE Oladipupo - Current opinion in chemical biology, 2022 - Elsevier
This review focuses on light-activated ruthenium anticancer compounds and the factors that
influence which pathway is favored. Photodynamic therapy (PDT) is favored by π expansion …

Ru (ii)/Os (ii)-based carbonic anhydrase inhibitors as photodynamic therapy photosensitizers for the treatment of hypoxic tumours

Y Wang, P Mesdom, K Purkait, B Saubaméa… - Chemical …, 2023 - pubs.rsc.org
Photodynamic therapy (PDT) is a medical technique for the treatment of cancer. It is based
on the use of non-toxic molecules, called photosensitizers (PSs), that become toxic when …

The anti-cancer effect of series of strained photoactivatable Ru (II) polypyridyl complexes on non-small-cell lung cancer and triple negative breast cancer cells

C Fayad, H Audi, RS Khnayzer, CF Daher - JBIC Journal of Biological …, 2021 - Springer
Ruthenium complexes have been recently reported as potential chemotherapeutic agents
that offer tumor selectivity and low tumor resistance. This study investigates the …

Non-aggregated lipophilic water-soluble tin porphyrins as photosensitizers for photodynamic therapy and photodynamic antimicrobial chemotherapy

B Babu, RC Soy, J Mack, T Nyokong - New Journal of Chemistry, 2020 - pubs.rsc.org
Two readily synthesized water-soluble Sn (IV) porphyrins have been prepared with
quaternized pyridyl nitrogens and 2-naphthalato trans-axial ligands. Methyl and hexyl …

A photoactivatable chemotherapeutic Ru (II) complex bearing bathocuproine ligand efficiently induces cell death in human malignant melanoma cells through a multi …

MG Elias, S Mehanna, E Elias, RS Khnayzer… - Chemico-Biological …, 2021 - Elsevier
Photoactivated chemotherapy (PACT) is an emerging strategy for targeted cancer therapy.
Strained Ru complexes with pseudo-octahedral geometry may undergo photo-induced …

Thien-2-yl substituted chlorins as photosensitizers for photodynamic therapy and photodynamic antimicrobial chemotherapy

B Babu, A Sindelo, J Mack, T Nyokong - Dyes and Pigments, 2021 - Elsevier
The synthesis and characterization of meso-tetra (thien-2-yl) chlorin (1) and meso-tetra (5-
bromothien-2-yl) chlorin (2) is reported. These dyes have red-shifted absorption maxima …

DFT Computational Analysis of the Mechanism of Action of Ru (II) Polypyridyl Complexes as Photoactivated Chemotherapy Agents: From Photoinduced Ligand …

F Ponte, D Belletto, R Leonetti, N Sanna… - Inorganic …, 2024 - ACS Publications
Photoactivated chemotherapy (PACT) is a form of target-oriented cancer therapy that
exploits light of the proper wavelength to selectively activate the drug. Among the prodrugs …

Ruthenium complexes with protic ligands: Influence of the position of oh groups and π expansion on luminescence and photocytotoxicity

OE Oladipupo, MC Prescott, ER Blevins… - International Journal of …, 2023 - mdpi.com
Protic ruthenium complexes using the dihydroxybipyridine (dhbp) ligand combined with a
spectator ligand (N, N= bpy, phen, dop, Bphen) have been studied for their potential activity …