Lipid-based nanoparticles for drug delivery systems

S Samimi, N Maghsoudnia, RB Eftekhari… - … and biology of …, 2019 - Elsevier
Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) have opened new
horizons in the pharmaceutical industry since they play a fundamental role in the field of …

50 years of oral lipid-based formulations: provenance, progress and future perspectives

OM Feeney, MF Crum, CL McEvoy, NL Trevaskis… - Advanced drug delivery …, 2016 - Elsevier
Lipid based formulations (LBF) provide well proven opportunities to enhance the oral
absorption of drugs and drug candidates that sit close to, or beyond, the boundaries of …

[HTML][HTML] Oral lipid-based drug delivery systems–an overview

S Kalepu, M Manthina, V Padavala - Acta Pharmaceutica Sinica B, 2013 - Elsevier
The formulation of drugs is carried out with the principle objective of enhancing their
bioavailability. Poorly water soluble drugs are challenging for the formulation scientists with …

Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates

N Blagden, M de Matas, PT Gavan, P York - Advanced drug delivery …, 2007 - Elsevier
The increasing prevalence of poorly soluble drugs in development provides notable risk of
new products demonstrating low and erratic bioavailabilty with consequences for safety and …

Lipid formulations for oral administration of drugs: non-emulsifying, self-emulsifying and 'self-microemulsifying'drug delivery systems

CW Pouton - European journal of pharmaceutical sciences, 2000 - Elsevier
'Lipid'formulations for oral administration of drugs generally consist of a drug dissolved in a
blend of two or more excipients, which may be triglyceride oils, partial glycerides, surfactants …

Bioavailability enhancement of poorly water-soluble drugs via nanocomposites: Formulation–Processing aspects and challenges

A Bhakay, M Rahman, RN Dave, E Bilgili - Pharmaceutics, 2018 - mdpi.com
Drug nanoparticles embedded in a dispersant matrix as a secondary phase, ie, drug-laden
nanocomposites, offer a versatile delivery platform for enhancing the dissolution rate and …

Self-microemulsifying drug delivery system (SMEDDS)–challenges and road ahead

S Dokania, AK Joshi - Drug delivery, 2015 - Taylor & Francis
Self-microemulsifying drug delivery system (SMEDDS) has emerged as a vital strategy to
formulate poor water soluble compounds for bioavailability enhancement. However, certain …

Common delivery systems for enhancing in vivo bioavailability and biological efficacy of nutraceuticals

Y Ting, Y Jiang, CT Ho, Q Huang - Journal of Functional Foods, 2014 - Elsevier
Nutraceuticals are an emerging food category defined as dietary elements which can
provide health benefits beyond the basic nutritional values. As more compounds have been …

Enhancement of gastrointestinal absorption of quercetin by solid lipid nanoparticles

HL Li, XB Zhao, YK Ma, GX Zhai, LB Li… - Journal of Controlled …, 2009 - Elsevier
The aim of the present study is to design and characterize quercetin-loaded solid lipid
nanoparticles (QT-SLNs), clarify the absorption mechanism of QT-SLNs and to evaluate the …

Formulation of self-emulsifying drug delivery systems

CW Pouton - Advanced drug delivery reviews, 1997 - Elsevier
Self-emulsifying drug delivery systems (SEDDS) are mixtures of oils and surfactants, ideally
isotropic, sometimes including cosolvents, which emulsify under conditions of gentle …