Decellularization in tissue engineering and regenerative medicine: evaluation, modification, and application methods

A Neishabouri, A Soltani Khaboushan… - … in bioengineering and …, 2022 - frontiersin.org
Reproduction of different tissues using scaffolds and materials is a major element in
regenerative medicine. The regeneration of whole organs with decellularized extracellular …

Decellularization strategies for regenerative medicine: from processing techniques to applications

A Gilpin, Y Yang - BioMed research international, 2017 - Wiley Online Library
As the gap between donors and patients in need of an organ transplant continues to widen,
research in regenerative medicine seeks to provide alternative strategies for treatment. One …

Methods of tissue decellularization used for preparation of biologic scaffolds and in vivo relevance

TJ Keane, IT Swinehart, SF Badylak - Methods, 2015 - Elsevier
Biologic scaffolds composed of extracellular matrix (ECM) are widely used in both preclinical
animal studies and in many clinical applications to repair and reconstruct tissues. Recently …

Designing decellularized extracellular matrix‐based bioinks for 3D bioprinting

A Abaci, M Guvendiren - Advanced healthcare materials, 2020 - Wiley Online Library
Abstract 3D bioprinting is an emerging technology to fabricate tissues and organs by
precisely positioning cells into 3D structures using printable cell‐laden formulations known …

An overview of tissue and whole organ decellularization processes

PM Crapo, TW Gilbert, SF Badylak - Biomaterials, 2011 - Elsevier
Biologic scaffold materials composed of extracellular matrix (ECM) are typically derived by
processes that involve decellularization of tissues or organs. Preservation of the complex …

Strategies for development of decellularized heart valve scaffolds for tissue engineering

Y Snyder, S Jana - Biomaterials, 2022 - Elsevier
Valvular heart diseases (VHDs) are currently treated using either mechanical or
bioprosthetic heart valves. Unfortunately, mechanical valves require lifelong anticoagulation …

Decellularized allogeneic and xenogeneic tissue as a bioscaffold for regenerative medicine: factors that influence the host response

SF Badylak - Annals of biomedical engineering, 2014 - Springer
Biologic scaffold materials composed of mammalian extracellular matrix (ECM) are prepared
by decellularization of source tissues harvested from either humans (allogeneic) or a variety …

Decellularized extracellular matrix: a step towards the next generation source for bioink manufacturing

BS Kim, H Kim, G Gao, J Jang, DW Cho - Biofabrication, 2017 - iopscience.iop.org
In tissue engineering, the need for hierarchical assembly of three-dimensional (3D) tissues
has become increasingly important, considering that new technology is essential for …

Biocompatibility evaluation of tissue-engineered decellularized scaffolds for biomedical application

KH Hussein, KM Park, KS Kang, HM Woo - Materials Science and …, 2016 - Elsevier
Biomaterials based on seeding of cells on decellularized scaffolds have gained increasing
interest in the last few years and suggested to serve as an alternative approach to …

Immunogenicity in xenogeneic scaffold generation: antigen removal vs. decellularization

ML Wong, LG Griffiths - Acta biomaterialia, 2014 - Elsevier
Decades of research have been undertaken towards the goal of tissue engineering using
xenogeneic scaffolds. The primary advantages associated with use of xenogeneic tissue …