Chronotherapeutics aim at treating illnesses according to the endogenous biologic rhythms,
which moderate xenobiotic metabolism and cellular drug response. The molecular clocks …

Bone‑related diseases comprise a large group of common diseases, including fractures,
osteoporosis and osteoarthritis (OA), which affect a large number of individuals, particularly …

Introduction Osteoarthritis (OA) is a heterogeneous and complex disease. We have used a
network biology approach based on genome-wide analysis of gene expression in OA knee …

The mammalian circadian clock regulates the day and night cycles of various physiological
functions. The circadian clock system consists of a central clock in the suprachiasmatic …

Metabolism is one of the most complex cellular biochemical reactions, providing energy and
substances for basic activities such as cell growth and proliferation. Early studies have …

A plethora of physiological processes show stable and synchronized daily oscillations that
are either driven or modulated by biological clocks. A circadian pacemaker located in the …

The circadian clock regulates tissue homeostasis through temporal control of tissue-specific
clock-controlled genes. In articular cartilage, disruptions in the circadian clock are linked to a …

The circadian clock is an autonomous molecular feedback loop inside almost every cell in
the body. We have shown that the mammary epithelial circadian clock is regulated by the …

CTGF is a multifunctional protein and plays different roles in different cells and under
different conditions. Pamrevlumab, a monoclonal antibody against CTGF, is an FDA …

Research over the past century indicates that the daily timing of physical activity impacts on
both immediate performance and long-term training efficacy. Recently, several molecular …