The visual/β-arrestins, a small family of proteins originally described for their role in the
desensitization and intracellular trafficking of G protein–coupled receptors (GPCRs), have …

Conventional orthosteric drug development programs targeting G protein-coupled receptors
(GPCRs) have focused on the concepts of agonism and antagonism, in which receptor …

The pathogen Staphylococcus aureus can readily develop antibiotic resistance and evade
the human immune system, which is associated with reduced levels of neutrophil …

Arrestins are multifunctional proteins that regulate G-protein-coupled receptor (GPCR)
desensitization, signaling, and internalization. The arrestin family consists of four subtypes …

Abstract Alzheimer's disease (AD), a late onset neurodegenerative disorder is characterized
by the loss of memory, disordered cognitive function, caused by accumulation of amyloid-β …

CC chemokine receptor 2 (CCR2) is a dual-function receptor. Similar to other G protein–
coupled chemokine receptors, it promotes monocyte infiltration into tissues in response to …

G protein-coupled receptor kinase type 2 (GRK2) and β-arrestin2 are representative proteins
that regulate the transduction and trafficking of G protein-coupled receptor (GPCR) …

Trace amines and their receptors (trace amine-associated receptors; TAARs) are an
emerging pharmacological target for the treatment of human disorders. While most studies …

Abstract Enterovirus 71 (EV71) is the main causative agent of hand, foot and mouth disease
(HFMD), which induces significantly elevated levels of cytokines and chemokines, leading to …

In ischemic vascular diseases, leukocyte recruitment and polarization are crucial for
revascularization and tissue repair. We investigated the role of vasodilator-stimulated …