Hypoxia-inducible factors and obstructive sleep apnea

NR Prabhakar, YJ Peng… - The Journal of clinical …, 2020 - Am Soc Clin Investig
Intermittent hypoxia (IH) is a hallmark manifestation of obstructive sleep apnea (OSA), a
widespread disorder of breathing. This Review focuses on the role of hypoxia-inducible …

Acute vs. chronic vs. cyclic hypoxia: their differential dynamics, molecular mechanisms, and effects on tumor progression

K Saxena, MK Jolly - Biomolecules, 2019 - mdpi.com
Hypoxia has been shown to increase the aggressiveness and severity of tumor progression.
Along with chronic and acute hypoxic regions, solid tumors contain regions of cycling …

NLRP3 deficiency protects against intermittent hypoxia-induced neuroinflammation and mitochondrial ROS by promoting the PINK1-parkin pathway of mitophagy in a …

X Wu, L Gong, L Xie, W Gu, X Wang, Z Liu… - Frontiers in …, 2021 - frontiersin.org
Obstructive sleep apnea (OSA) associated neurocognitive impairment is mainly caused by
chronic intermittent hypoxia (CIH)-triggered neuroinflammation and oxidative stress …

Reviewing the relationship between OSA and cognition: W here do we go from here?

RS Bucks, M Olaithe, I Rosenzweig, MJ Morrell - Respirology, 2017 - Wiley Online Library
Obstructive sleep apnoea (OSA) is a disorder of breathing during sleep resulting in
temporary reduction in cerebral oxygenation and sleep disruption. A growing body of …

NLRP3 inflammasome in cognitive impairment and pharmacological properties of its inhibitors

Y Xu, Y Yang, X Chen, D Jiang, F Zhang, Y Guo… - Translational …, 2023 - Springer
Cognitive impairment is a multifactorial and multi-step pathological process that places a
heavy burden on patients and the society. Neuroinflammation is one of the main factors …

[HTML][HTML] Obstructive sleep apnoea and Alzheimer's disease: in search of shared pathomechanisms

D Polsek, N Gildeh, D Cash… - Neuroscience & …, 2018 - Elsevier
Alzheimer's disease (AD) is a significant public health concern. The incidence continues to
rise, and it is set to be over one million in the UK by 2025. The processes involved in the …

Altered structural brain network resulting from white matter injury in obstructive sleep apnea

MH Lee, CH Yun, A Min, YH Hwang, SK Lee, DY Kim… - Sleep, 2019 - academic.oup.com
Abstract Study Objectives To assess, using fractional anisotropy (FA) analysis, alterations of
brain network connectivity in adults with obstructive sleep apnea (OSA). Abnormal networks …

A HIF1a-dependent pro-oxidant state disrupts synaptic plasticity and impairs spatial memory in response to intermittent hypoxia

A Arias-Cavieres, MA Khuu, CU Nwakudu, JE Barnard… - eneuro, 2020 - eneuro.org
Sleep apnea causes cognitive deficits and is associated with several neurologic diseases.
Intermittent hypoxia (IH) is recognized as a principal mediator of pathophysiology associated …

[HTML][HTML] Changes and significance of SYP and GAP-43 expression in the hippocampus of CIH rats

X Zhu, P Wang, H Liu, J Zhan, J Wang… - … journal of medical …, 2019 - ncbi.nlm.nih.gov
Synaptophysin (SYP) and growth-associated binding protein 43 (GAP-43) have been shown
to be closely related to hippocampal synaptic plasticity in recent years. They are important …

Obstructive sleep apnea and nocturnal hypoxemia are associated with an increased risk of lung cancer

LM Seijo, MT Pérez-Warnisher, LF Giraldo-Cadavid… - Sleep medicine, 2019 - Elsevier
Study objectives To identify a link between sleep disordered breathing, nocturnal
hypoxemia, and lung cancer. Methods We conducted a cross-sectional study of a combined …