Methylation is a well‐known structural modification in organic and medicinal chemistry. This
review summarizes recent advances in methylation by categorizing specific methylation …

Indazole-containing derivatives represent one of the most important heterocycles in drug
molecules. Diversely substituted indazole derivatives bear a variety of functional groups and …

The G-protein coupled receptors (GPCRs) activated by free fatty acids (FFAs) have emerged
as new and exciting drug targets, due to their plausible translation from pharmacology to …

Free fatty acids (FFAs) present in our dietary fats not only act as vital nutrients but also
function as signalling molecules and modulate key biological functions through their active …

Unsaturated long-chain fatty acids have been suggested to be beneficial in the context of
cardiovascular disorders based in epidemiologic studies conducted in Greenland and …

Taking a previously discovered indazole derivative 1 as a lead, systematic structural
modifications were performed with an indazole core at the 1-and 6-positions to improve its …

A new series of 1 H-pyrrolo [3, 2-c] pyridine derivatives were designed and synthesised as
colchicine-binding site inhibitors. Preliminary biological evaluations showed that most of the …

FFA4 is a novel therapeutic target for the treatment of metabolic diseases, such as type II
diabetes. However, there are still few ligands with structural diversity, selectivity and high …

GPR120 is a promising target for the treatment of type 2 diabetes (T2DM), which is activated
by free fatty acids (FFAs) and stimulates the release of glucagon-like peptide-1 (GLP-1). GLP …

α-Arylations of cyclopropyl and related nitriles provide access to important synthetic
intermediates and pharmacophores for biologically active molecules. However, robust …