[HTML][HTML] The role of structure and biophysical properties in the pleiotropic effects of statins

C Murphy, E Deplazes, CG Cranfield… - International journal of …, 2020 - mdpi.com
Statins are a class of drugs used to lower low-density lipoprotein cholesterol and are
amongst the most prescribed medications worldwide. Most statins work as a competitive …

Statin action targets lipid rafts of cell membranes: GIXD/PM-IRRAS investigation of Langmuir monolayers

M Zaborowska, M Broniatowski… - The Journal of …, 2023 - ACS Publications
Lipid rafts are condensed regions of cell membranes rich in cholesterol and sphingomyelin,
which constitute the target for anticholesterolemic drugs-statins. In this work, we use for the …

[HTML][HTML] Structural modifications of lipid membranes exposed to statins–Langmuir monolayer and PM-IRRAS study

M Zaborowska, M Broniatowski, P Wydro… - Journal of Molecular …, 2020 - Elsevier
The effects of selected statins on the structure and properties of lipid membranes composed
of zwitterionic (1, 2-dimyristoyl-sn-glycero-3-phosphocholine, DMPC, 1, 2-dimyristoyl-sn …

[HTML][HTML] Surface and electrochemical properties of lipid raft model membranes and how they are affected by incorporation of statin

M Zaborowska, D Dziubak, D Matyszewska… - Electrochimica Acta, 2021 - Elsevier
Cerivastatin belongs to the class of statins, drugs lowering blood cholesterol level by
inhibiting the enzyme HMG-CoA reductase. The enzyme is located in the endoplasmic …

[HTML][HTML] Incorporation of simvastatin into lipid membranes: Why deliver a statin in form of inclusion complex with hydrophilic cyclodextrin

A Bartkowiak, D Matyszewska, A Krzak… - Colloids and Surfaces B …, 2021 - Elsevier
In this work, the effects of simvastatin (SIM),(2-hydroxypropyl)-β-cyclodextrin (HPβCD) and
their complex (SIM: HPβCD) on the structure and properties of lipid membranes were …

[HTML][HTML] Is lipophilicity the main factor determining the effective drug penetration through lipid membranes? Combined GIXD and PM-IRRAS studies on the example of …

D Matyszewska, M Zaborowska, P Fontaine - Journal of Molecular Liquids, 2023 - Elsevier
Cell membranes constitute the first barrier for the drugs on their way to the cell. Therefore,
their penetration determines the effectivity of the treatment and is defined by the drug-lipid …

Photophysical and nonlinear optical properties of azophloxine in reverse micelles

S Sharifi, GL Faritovna, A Azarpour - Journal of Fluorescence, 2018 - Springer
The photophysical and nonlinear optical properties of Azophloxine in Reverse micelle (RM)
and dye-surfactant interaction were studied using Z-scan, spectrophotometer, and …

Optical Properties of Methyl Orange-Doped Droplet and Photodynamic Therapy of Staphylococcus aureus

S Sharifi, SG Salavatovna, A Azarpour… - Journal of …, 2019 - Springer
Dye-doped droplets are known as mixtures of dyes with uniform solutions of water droplets
in a continuous phase of oils with surfactants. To observe the relationship between water …

Modulation of phospholipid bilayer properties by simvastatin

RD Teo, DP Tieleman - The Journal of Physical Chemistry B, 2021 - ACS Publications
Simvastatin (Zocor) is one of the most prescribed drugs for reducing high cholesterol.
Although simvastatin is ingested in its inactive lactone form, it is converted to its active …

Interaction of lovastatin with model membranes by NMR data and from MD simulations

GS Shurshalova, AR Yulmetov, DA Sharapova… - Bionanoscience, 2020 - Springer
Lovastatin is a drug of the statin group which possesses the ability to decrease low-density
lipoprotein cholesterol level by the competitive inhibition of 3-hydroxy-3-methylglutaryl …