A human embryo's legal definition and its entitlement to protection vary greatly worldwide.
Recently, human pluripotent stem cells have been used to form in vitro models of early …

The development of an organism depends on intrinsic genetic programs of progenitor cells
and their spatiotemporally complex extrinsic environment. Ex vivo generation of organoids …

The human embryo undergoes morphogenetic transformations following implantation into
the uterus, but our knowledge of this crucial stage is limited by the inability to observe the …

Embryonic stem (ES) cells can undergo many aspects of mammalian embryogenesis in
vitro,,,–, but their developmental potential is substantially extended by interactions with …

The ability to study human post-implantation development remains limited owing to ethical
and technical challenges associated with intrauterine development after implantation …

In vitro stem cell models that replicate human gastrulation have been generated, but they
lack the essential extraembryonic cells needed for embryonic development, morphogenesis …

Human stem cell-derived blastoids display similar morphology and cell lineages to normal
blastocysts. However, the ability to investigate their developmental potential is limited. Here …

Several in vitro models have been developed to recapitulate mouse embryogenesis solely
from embryonic stem cells (ESCs). Despite mimicking many aspects of early development …

The third and fourth weeks of gestation in primates are marked by several developmental
milestones, including gastrulation and the formation of organ primordia. However, our …

The evolution of embryo models | Nature Methods Skip to main content Thank you for
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