Context: Insulin resistance is an almost universal finding in nonalcoholic fatty liver disease
(NAFLD). This review outlines the evidence linking insulin resistance and NAFLD, explores …

Human adiposity has long been associated with insulin resistance and increased
cardiovascular risk, and abdominal adiposity is considered particularly adverse. Intra …

A key goal of biomedical research is to elucidate the complex network of gene interactions
underlying complex traits such as common human diseases. Here we detail a multistep …

Reports of the predictive value of minor elevation of serum C-reactive protein (CRP) levels
(between 3 and 10 mg/L) for atherosclerotic events have generated considerable interest, as …

Alzheimer disease (AD) and type 2 diabetes mellitus (T2DM) are conditions that affect a
large number of people in the industrialized countries. Both conditions are on the increase …

Primary empty sella (PES) is characterized by the herniation of the subarachnoid space
within the sella, which is often associated with variable degrees of flattening of the pituitary …

The epidemic of obesity in the developed world over the last two decades is driving a large
increase in type 2 diabetes and consequentially setting the scene for an impending wave of …

Nonalcoholic fatty liver disease represents a spectrum of histopathologic abnormalities, the
prevalence of which may be as high as 24% of the population of the United States …

The metabolic syndrome is a cluster of common pathologies: abdominal obesity linked to an
excess of visceral fat, insulin resistance, dyslipidemia and hypertension. At the molecular …

Stroke affects more than 700,000 in-dividuals each year; it is the third largest cause of death
and the largest cause of adult disability in the US Diabetes is a major risk factor for the …