Proton-pump inhibitors: understanding the complications and risks

P Malfertheiner, A Kandulski, M Venerito - … Reviews Gastroenterology & …, 2017 - nature.com
Proton-pump inhibitors (PPIs) are the most effective therapy for the full spectrum of gastric-
acid-related diseases. However, in the past decade, a steadily increasing list of …

Adverse effects of proton pump inhibitors—evidence and plausibility

R Fossmark, TC Martinsen, HL Waldum - International journal of …, 2019 - mdpi.com
Proton pump inhibitors (PPIs) have been increasingly used over the last decades and there
are concerns about overuse and the numerous reported side-effects. It is uncertain whether …

Proton pump inhibitors and risk of incident CKD and progression to ESRD

Y Xie, B Bowe, T Li, H Xian… - Journal of the …, 2016 - journals.lww.com
The association between proton pump inhibitors (PPI) use and risk of acute interstitial
nephritis has been described. However, whether exposure to PPI associates with incident …

[HTML][HTML] Risk of death among users of proton pump inhibitors: a longitudinal observational cohort study of United States veterans

Y Xie, B Bowe, T Li, H Xian, Y Yan, Z Al-Aly - BMJ open, 2017 - bmjopen.bmj.com
Objective Proton pump inhibitors (PPIs) are widely used, and their use is associated with
increased risk of adverse events. However, whether PPI use is associated with excess risk of …

Mechanisms of proton pump inhibitor‐induced hypomagnesemia

LMM Gommers, JGJ Hoenderop… - Acta …, 2022 - Wiley Online Library
Proton pump inhibitors (PPIs) reliably suppress gastric acid secretion and are therefore the
first‐line treatment for gastric acid‐related disorders. Hypomagnesemia (serum magnesium …

Proton pump inhibitors linked to hypomagnesemia: a systematic review and meta-analysis of observational studies

W Cheungpasitporn, C Thongprayoon… - Renal failure, 2015 - Taylor & Francis
Background: The reported risk of hypomagnesemia in patients with proton pump inhibitor
(PPI) use is conflicting. The objective of this meta-analysis was to assess the association …

Proton pump inhibitors and hypomagnesemia: A meta-analysis of observational studies

T Srinutta, A Chewcharat, K Takkavatakarn… - Medicine, 2019 - journals.lww.com
Background: Previous meta-analyses have suggested that there might be an association
between the use of proton pump inhibitors (PPIs) and the development of hypomagnesemia …

Proton pump inhibitors and the kidney: implications of current evidence for clinical practice and when and how to deprescribe

Z Al-Aly, G Maddukuri, Y Xie - American Journal of Kidney Diseases, 2020 - Elsevier
Proton pump inhibitors (PPIs), long thought to be safe, are associated with a number of
nonkidney adverse health outcomes and several untoward kidney outcomes, including …

The association between the use of proton pump inhibitors and the risk of hypomagnesemia: a systematic review and meta-analysis

CH Park, EH Kim, YH Roh, HY Kim, SK Lee - PloS one, 2014 - journals.plos.org
Background Although many case reports have described patients with proton pump inhibitor
(PPI)-induced hypomagnesemia, the impact of PPI use on hypomagnesemia has not been …

Proton pump inhibitors and hypomagnesemia in the general population: a population-based cohort study

BCT Kieboom, JC Kiefte–de Jong… - American Journal of …, 2015 - Elsevier
Background Proton pump inhibitor (PPI) use has been associated with hypomagnesemia in
case reports and hospital-based cohort studies. Our objective was to determine whether PPI …