Quantitative magnetic resonance imaging (qMRI) goes beyond conventional MRI, which
aims primarily at local image contrast. It provides specific physical parameters related to the …

Life exists in three dimensions, but until the turn of the century most electron microscopy
methods provided only 2D image data. Recently, electron microscopy techniques capable of …

Brains contain networks of interconnected neurons and so knowing the network architecture
is essential for understanding brain function. We therefore mapped the synaptic-resolution …

UCSF ChimeraX is the next‐generation interactive visualization program from the Resource
for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX …

The human cerebral cortex houses 1000 times more neurons than that of the cerebral cortex
of a mouse, but the possible differences in synaptic circuits between these species are still …

Neurons in the developing brain undergo extensive structural refinement as nascent circuits
adopt their mature form. This physical transformation of neurons is facilitated by the …

We acquired a rapidly preserved human surgical sample from the temporal lobe of the
cerebral cortex. We stained a 1 mm3 volume with heavy metals, embedded it in resin, cut …

We assembled a semi-automated reconstruction of L2/3 mouse primary visual cortex from∼
250× 140× 90 μm 3 of electron microscopic images, including pyramidal and non-pyramidal …

In 1986, electron microscopy was used to reconstruct by hand the entire nervous system of a
roundworm, the nematode Caenorhabditis elegans. Since this landmark study, high …

Developing neurons connect in specific and stereotyped ways to form the complex circuits
that underlie brain function. By comparison to earlier steps in neural development, progress …