Chromatin inheritance entails de novo nucleosome assembly after DNA replication by
chromatin assembly factor-1 (CAF-1). Yet direct knowledge about CAF-1's histone binding …

During every cell cycle, both the genome and the associated chromatin must be accurately
replicated. Chromatin Assembly Factor-1 (CAF-1) is a key regulator of chromatin replication …

Cellular plasticity progressively declines with development and differentiation, yet these
processes can be experimentally reversed by reprogramming somatic cells to induced …

Increasing soil salinization has led to severe reductions in plant yield and quality, and
investigating the molecular mechanism of salt stress response is therefore an urgent priority …

Control of cellular identity requires coordination of developmental programs with
environmental factors such as nutrient availability, suggesting that perturbing metabolism …

BCL-2 inhibitors such as venetoclax offer therapeutic promise in acute myeloid leukemia
(AML) and other cancers, but drug resistance poses a significant challenge. It is crucial to …

Abstract Purpose of Review Hematopoietic stem cells (HSCs) occupy the summit of the
intricate hematopoiesis hierarchy, constituting a mere 0.01% of the adult bone marrow. The …

The role of chromatin biology and epigenetics in disease progression is gaining increasing
recognition. Genes that escape X chromosome inactivation (XCI) can impact …

Those who study macrophage biology struggle with the decision whether to utilize primary
macrophages derived directly from mice or opt for the convenience and genetic tractability of …

Acute myeloid leukemia (AML) is an aggressive blood cancer that stems from the rapid
expansion of immature leukemic blasts in the bone marrow. Mutations in epigenetic factors …