RNA-binding proteins in cancer: functional and therapeutic perspectives
D Kang, Y Lee, JS Lee - Cancers, 2020 - mdpi.com
Simple Summary RNA-binding proteins (RBPs) play central roles in regulating
posttranscriptional expression of genes. Many of them are known to be deregulated in a …
posttranscriptional expression of genes. Many of them are known to be deregulated in a …
[HTML][HTML] RNA binding proteins (RBPs) and their role in DNA damage and radiation response in cancer
Traditionally majority of eukaryotic gene expression is influenced by transcriptional and post-
transcriptional events. Alterations in the expression of proteins that act post-transcriptionally …
transcriptional events. Alterations in the expression of proteins that act post-transcriptionally …
[HTML][HTML] Multi-level functional genomics reveals molecular and cellular oncogenicity of patient-based 3′ untranslated region mutations
Summary 3′ untranslated region (3′ UTR) somatic mutations represent a largely
unexplored avenue of alternative oncogenic gene dysregulation. To determine the …
unexplored avenue of alternative oncogenic gene dysregulation. To determine the …
RNA-binding proteins in the regulation of adipogenesis and adipose function
P Zhang, W Wu, C Ma, C Du, Y Huang, H Xu, C Li… - Cells, 2022 - mdpi.com
The obesity epidemic represents a critical public health issue worldwide, as it is a vital risk
factor for many diseases, including type 2 diabetes (T2D) and cardiovascular disease …
factor for many diseases, including type 2 diabetes (T2D) and cardiovascular disease …
MiR-26 down-regulates TNF-α/NF-κB signalling and IL-6 expression by silencing HMGA1 and MALT1
MiR-26 has emerged as a key tumour suppressor in various cancers. Accumulating
evidence supports that miR-26 regulates inflammation and tumourigenicity largely through …
evidence supports that miR-26 regulates inflammation and tumourigenicity largely through …
Diverse roles of the nucleic acid‐binding protein KHSRP in cell differentiation and disease
The single‐stranded nucleic acid‐binding protein KHSRP (KH‐type splicing regulatory
protein) modulates RNA life and gene expression at various levels. KHSRP controls …
protein) modulates RNA life and gene expression at various levels. KHSRP controls …
mRNA degradation by the endoribonuclease Regnase-1/ZC3H12a/MCPIP-1
T Uehata, S Akira - Biochimica et Biophysica Acta (BBA)-Gene Regulatory …, 2013 - Elsevier
Post-transcriptional regulation is a crucial step for coordinating immune responses. Post-
transcriptional mechanisms exquisitely control inflammation by increasing or decreasing …
transcriptional mechanisms exquisitely control inflammation by increasing or decreasing …
The versatile role of HuR in Glioblastoma and its potential as a therapeutic target for a multi-pronged attack
Glioblastoma (GBM) is a malignant and aggressive brain tumor with a median survival of∼
15 months. Resistance to treatment arises from the extensive cellular and molecular …
15 months. Resistance to treatment arises from the extensive cellular and molecular …
The role of mammalian MAPK signaling in regulation of cytokine mRNA stability and translation
Extracellular-regulated kinases and p38 mitogen-activated protein kinases are activated in
innate (and adaptive) immunity and signal via different routes to alter the stability and …
innate (and adaptive) immunity and signal via different routes to alter the stability and …
AU-rich-element-dependent translation repression requires the cooperation of tristetraprolin and RCK/P54
MY Qi, ZZ Wang, Z Zhang, Q Shao, A Zeng… - … and cellular biology, 2012 - Am Soc Microbiol
Abstract AU-rich elements (AREs), residing in the 3′ untranslated region (UTR) of many
labile mRNAs, are important cis-acting elements that modulate the stability of these mRNAs …
labile mRNAs, are important cis-acting elements that modulate the stability of these mRNAs …