▪ Abstract We can now assign about two thirds of the sequences from completed genomes to
as few as 1400 domain families for which structures are known and thus more ancient …

Classifications of proteins into groups of related sequences are in some respects like a
periodic table for biology, allowing us to understand the underlying molecular biology of any …

By exploiting three-dimensional structure comparison, which is more sensitive than
conventional sequence-based methods for detecting remote homology, we have identified a …

We present the structural annotation of 56 different bacterial species based on the
assignment of genes to 816 evolutionary superfamilies in the CATH domain structure …

Background Protein structural domains are evolutionary units whose relationships can be
detected over long evolutionary distances. The evolutionary history of protein domains …

Although the precise aims differ between the various international structural genomics
initiatives currently aiming to illuminate the universe of protein folds, many selectively target …

Detailed knowledge of the three-dimensional structures of biological molecules has had an
enormous impact on all areas of biological science, including genetics, as structure can …

Structural genomics is an international effort to determine the three‐dimensional shapes of
all important biological macromolecules, with a primary focus on proteins. Target proteins …

Protein evolution is imprinted in both the sequence and the structure of evolutionary building
blocks known as protein domains. These domains share a common ancestry and can be …

Chimeric oncoproteins created by chromosomal translocations are among the most common
genetic mutations associated with tumorigenesis. Malignant mucoepidermoid salivary gland …