G protein-coupled receptors (GPCRs) are embedded in phospholipids that strongly
influence drug-stimulated signaling. Anionic lipids are particularly important for GPCR …

One-third of current pharmaceuticals target G protein-coupled receptors (GPCRs), the
largest receptor superfamily in humans and mediators of diverse physiological processes …

Integral membrane proteins (IMPs) play central roles in cellular physiology and represent
the majority of known drug targets. Single-molecule fluorescence and fluorescence …

Cholesterol is a critical component of mammalian cell membranes and an allosteric
modulator of G protein-coupled receptors (GPCRs), but divergent views exist on the …

Mutations that constitutively activate G protein-coupled receptors (GPCRs), known as
constitutively activating mutations (CAMs), modify cell signaling and interfere with drugs …

The conformational ensembles of G protein-coupled receptors (GPCRs) include inactive and
active states. Spectroscopy techniques, including NMR, show that agonists, antagonists and …

Dynamic information is vital to understanding the activation mechanism of G protein-coupled
receptors (GPCRs). Despite the availability of high-resolution structures of different …

G protein-coupled receptor (GPCR) conformational plasticity enables formation of ternary
signaling complexes with intracellular proteins in response to binding extracellular ligands …

G protein-coupled receptors (GPCRs) are membrane proteins targeted by over one-third of
marketed drugs. Understanding their activation mechanism is essential for precise …

The complex pharmacology of G-protein-coupled receptors (GPCRs) is defined by their multi-
state conformational dynamics. Single-molecule Förster Resonance Energy Transfer …