Regulatory R-loops as facilitators of gene expression and genome stability
C Niehrs, B Luke - Nature reviews Molecular cell biology, 2020 - nature.com
R-loops are three-stranded structures that harbour an RNA–DNA hybrid and frequently form
during transcription. R-loop misregulation is associated with DNA damage, transcription …
during transcription. R-loop misregulation is associated with DNA damage, transcription …
[HTML][HTML] Emergence and adaptation of the cellular machinery directing antigenic variation in the African trypanosome
Survival of the African trypanosome within its mammalian hosts, and hence transmission
between hosts, relies upon antigenic variation, where stochastic changes in the composition …
between hosts, relies upon antigenic variation, where stochastic changes in the composition …
TbTRF suppresses the TERRA level and regulates the cell cycle-dependent TERRA foci number with a TERRA binding activity in its C-terminal Myb domain
Telomere repeat-containing RNA (TERRA) has been identified in multiple organisms
including Trypanosoma brucei, a protozoan parasite that causes human African …
including Trypanosoma brucei, a protozoan parasite that causes human African …
RAD51-mediated R-loop formation acts to repair transcription-associated DNA breaks driving antigenic variation in Trypanosoma brucei
MJ Girasol, M Krasilnikova… - Proceedings of the …, 2023 - National Acad Sciences
RNA–DNA hybrids are epigenetic features of all genomes that intersect with many
processes, including transcription, telomere homeostasis, and centromere function …
processes, including transcription, telomere homeostasis, and centromere function …
Trypanosoma brucei ribonuclease H2A is an essential R-loop processing enzyme whose loss causes DNA damage during transcription initiation and antigenic …
Ribonucleotides represent a threat to DNA genome stability and transmission. Two types of
Ribonuclease H (RNase H) excise ribonucleotides when they form part of the DNA strand, or …
Ribonuclease H (RNase H) excise ribonucleotides when they form part of the DNA strand, or …
Telomere and subtelomere R-loops and antigenic variation in trypanosomes
Trypanosoma brucei is a kinetoplastid parasite that causes African trypanosomiasis, which
is fatal if left untreated. T. brucei regularly switches its major surface antigen, VSG, to evade …
is fatal if left untreated. T. brucei regularly switches its major surface antigen, VSG, to evade …
Read, write, adapt: challenges and opportunities during kinetoplastid genome replication
The genomes of all organisms are read throughout their growth and development,
generating new copies during cell division and encoding the cellular activities dictated by …
generating new copies during cell division and encoding the cellular activities dictated by …
Evaluation of mechanisms that may generate DNA lesions triggering antigenic variation in African trypanosomes
Antigenic variation by variant surface glycoprotein (VSG) coat switching in African
trypanosomes is one of the most elaborate immune evasion strategies found among …
trypanosomes is one of the most elaborate immune evasion strategies found among …
Trypanosoma brucei ATR links DNA damage signaling during antigenic variation with regulation of RNA polymerase I-transcribed surface antigens
JA Black, K Crouch, L Lemgruber, C Lapsley… - Cell reports, 2020 - cell.com
Trypanosoma brucei evades mammalian immunity by using recombination to switch its
surface-expressed variant surface glycoprotein (VSG), while ensuring that only one of many …
surface-expressed variant surface glycoprotein (VSG), while ensuring that only one of many …
The RNA export factor TbMex67 connects transcription and RNA export in Trypanosoma brucei and sets boundaries for RNA polymerase I
B Pozzi, A Naguleswaran, F Florini… - Nucleic acids …, 2023 - academic.oup.com
TbMex67 is the major mRNA export factor known to date in trypanosomes, forming part of
the docking platform within the nuclear pore. To explore its role in co-transcriptional mRNA …
the docking platform within the nuclear pore. To explore its role in co-transcriptional mRNA …