Antimicrobial peptides: diversity, mechanism of action and strategies to improve the activity and biocompatibility in vivo

P Kumar, JN Kizhakkedathu, SK Straus - Biomolecules, 2018 - mdpi.com
Antibiotic resistance is projected as one of the greatest threats to human health in the future
and hence alternatives are being explored to combat resistance. Antimicrobial peptides …

[HTML][HTML] Antimicrobial peptides: new hope in the war against multidrug resistance

J Mwangi, X Hao, R Lai, ZY Zhang - Zoological research, 2019 - ncbi.nlm.nih.gov
The discovery of antibiotics marked a golden age in the revolution of human medicine.
However, decades later, bacterial infections remain a global healthcare threat, and a return …

[HTML][HTML] Antimicrobial peptides with selective antitumor mechanisms: prospect for anticancer applications

B Deslouches, YP Di - Oncotarget, 2017 - ncbi.nlm.nih.gov
In the last several decades, there have been significant advances in anticancer therapy.
However, the development of resistance to cancer drugs and the lack of specificity related to …

[HTML][HTML] Advancements, challenges and future perspectives on peptide-based drugs: Focus on antimicrobial peptides

X Luo, H Chen, Y Song, Z Qin, L Xu, N He, Y Tan… - European Journal of …, 2023 - Elsevier
Among other health related issues, the rising concerns on drug resistance led to look for
alternative pharmaceutical drugs that are effective both against infectious and noninfectious …

Multifunctional cationic host defence peptides and their clinical applications

ATY Yeung, SL Gellatly, REW Hancock - Cellular and Molecular Life …, 2011 - Springer
With the rapid rise in the emergence of bacterial strains resistant to multiple classes of
antimicrobial agents, there is an urgent need to develop novel antimicrobial therapies to …

Cationic host defense (antimicrobial) peptides

KL Brown, REW Hancock - Current opinion in immunology, 2006 - Elsevier
Members of the cationic host defense (antimicrobial) peptide family are widely distributed in
nature, existing in organisms from insects to plants to mammals and non-mammalian …

Antimicrobial peptides: versatile biological properties

M Pushpanathan, P Gunasekaran… - International journal of …, 2013 - Wiley Online Library
Antimicrobial peptides are diverse group of biologically active molecules with
multidimensional properties. In recent past, a wide variety of AMPs with diverse structures …

Controlling macromolecular structures towards effective antimicrobial polymers

MS Ganewatta, C Tang - Polymer, 2015 - Elsevier
Drug resistance of pathogenic bacteria is a major global problem leading humanity towards
a pre-antibiotic era. Decline in the discovery of novel antibiotics and the lack of a resilient …

Antimicrobial peptides on calcium phosphate-coated titanium for the prevention of implant-associated infections

M Kazemzadeh-Narbat, J Kindrachuk, K Duan… - Biomaterials, 2010 - Elsevier
Prevention of implant-associated infections has been one of the main challenges in
orthopaedic surgery. This challenge is further complicated by the concern over the …

Ultrashort antibacterial and antifungal lipopeptides

A Makovitzki, D Avrahami… - Proceedings of the …, 2006 - National Acad Sciences
Host-defense cationic antimicrobial peptides (≈ 12–50 aa long) play an essential protective
role in the innate immune system of all organisms. Lipopeptides, however, are produced …